Publications by authors named "Satpal Singh Bisht"

High-altitude mammals are often subject to specific environmental obstacles, which exert selective pressure on their physiological and morphological traits, hence driving their evolutionary processes. It is anticipated that these circumstances will lead to the adaptive evolution of protein-coding genes (PCGs) in the mitochondrial genome, which play a crucial role in the oxidative phosphorylation system. In this study, we have generated the complete mitochondrial genome of the Badri breed of Bos indicus inhabiting a high-altitude environment to test the signatures of adaptive evolution on PCGs and their phylogenetic relationships.

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Rice landraces conserved by tribal farmers are important for their nutritional richness. Landraces are rich in essential amino acids, vitamins, anthocyanins, and flavonoids useful to cure noncommunicable diseases and metabolic disorders. A study was carried out with 10 rice landraces from the tribal-dominated belt of Southern Odisha to investigate grain nutrition, proximate composition, and vitamin and mineral contents.

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The ability of microorganisms to detoxify xenobiotic compounds allows them to thrive in a toxic environment using carbon, phosphorus, sulfur, and nitrogen from the available sources. Biotransformation is the most effective and useful metabolic process to degrade xenobiotic compounds. Microorganisms have an exceptional ability due to particular genes, enzymes, and degradative mechanisms.

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SagS sensor regulator plays a vital role in biofilm development of which subsequently makes the cells more tolerant to various antimicrobials. The multidrug resistance (MDR) issue has risen substantially in recent years and is considered a global threat. Therefore, alternative compounds should be unearthed immediately to address the issues related to drug resistance for which SagS could be a candidate.

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Article Synopsis
  • Pathogenic microorganisms, especially those forming biofilms, pose challenges in biomedical research due to their multidrug resistance and persistent infections.
  • Researchers are exploring natural anti-biofilm agents, such as phytochemicals and biosurfactants, that offer better efficacy and lower toxicity compared to synthetic antibiotics.
  • The review highlights various natural compounds' mechanisms of action against biofilms, suggesting their potential to be combined for enhanced therapeutic strategies against multiple pathogenic species.
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Earthworms are important organisms in soil communities and are known for sustaining the life of the soil. They are used as a model organism in environmental risk assessment of chemicals and soil toxicology. Soil provides physical and nutritive support to agriculture system by regulating biogeochemical cycles, nutrient cycle, waste degradation, organic matter degradation .

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  • The study explored the bacterial and archaeal diversity in two alkaline hot springs in India, Jakrem and Yumthang, identifying key dominant phyla and genera in each.
  • In Jakrem, dominant bacteria included Firmicutes, Chloroflexi, and Thermi, while Yumthang was mainly characterized by Proteobacteria, with specific genera like Clostridium and Thiobacillus noted.
  • Additionally, the research highlighted the role of certain bacteria in the sulfur cycle and suggested the presence of numerous unknown microbial sequences, indicating a rich and unexplored microbial diversity in these hot springs.
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  • Mizoram's caves are potential biodiversity hotspots due to the geologically rich Indo-Burman plateau and their largely unexplored ecosystems.
  • Advanced genomic sequencing of the bacterial communities in three caves showed the discovery of 10,643 operational taxonomic units (OTUs) with dominant groups including Planctomycetes, Actinobacteria, and Proteobacteria.
  • Notable differences in microbial diversity were observed across the caves, with one cave showing low diversity primarily dominated by Actinobacteria and a large number of unidentified OTUs, indicating the possibility of new species that require further genomic analysis to understand their roles.
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Bacterial community of the Khuangcherapuk cave sediment was assessed by Illumina amplicon sequencing. The metagenome comprised of 533,120 raw reads with an average base quality (Phred score) 36.75 and G + C content is 57.

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  • Jakrem hot water spring, located in Meghalaya's West Khasi Hill District, is renowned for its supposed healing properties for skin ailments and is a notable hot spring in the area.
  • This study presents the first analysis of the V3 hyper-variable region of 16S rDNA metagenome sequences from the hot spring, using the Illumina platform, which generated over 10 million raw sequences.
  • The analysis identified 694 operational taxonomic units (OTUs) from 14 bacterial phyla, revealing a microbial community dominated by Firmicutes, Chloroflexi, and Cyanobacteria, with sequence data accessible on the NCBI SRA database.
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V4 hypervariable region of 16S rDNA was analyzed for identifying the bacterial communities present in Bat Guano from the unexplored cave - Pnahkyndeng, Meghalaya, Northeast India. Metagenome comprised of 585,434 raw Illumina sequences with a 59.59% G+C content.

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The significance of Brevibacillus has been documented scientifically in the published literature and commercially in heterologous recombinant protein catalogs. Brevibacillus is one of the most widespread genera of Gram-positive bacteria, recorded from the diverse environmental habitats. The high growth rate, better transformation efficiency by electroporation, availability of shuttle vectors, production of negligible amount of extracellular protease, and the constitutive expression of heterologous proteins make some strains of this genus excellent laboratory models.

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The root of Hemidesmus indicus R. Br., commonly known as Indian Sarsaparilla, is used traditionally to treat a wide variety of illnesses including rheumatism, leprosy, impotence, urinary tract and skin infections.

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