Publications by authors named "Satoshi Tsukushi"
Article Synopsis
- * It aims to determine if having surgery followed by three courses of adjuvant chemotherapy is as effective as the standard approach of chemotherapy followed by surgery and then more chemotherapy.
- * The trial is a large, randomized phase III study that began in November 2022 and seeks to confirm that the new treatment method is not inferior regarding overall survival rates.
Article Synopsis
- A multicenter study in Japan compared clinical outcomes for patients with pelvic bone sarcomas treated with surgery versus particle beam therapy (carbon-ion and proton).
- The study included 116 patients, with 57 receiving surgery and 59 undergoing particle beam therapy, revealing differences in median age at diagnosis and tumor size between the groups.
- Overall survival, local control, and metastasis-free survival rates were similar between the groups, but in chordoma patients, the particle beam therapy showed significantly better local control rates compared to surgery.
Article Synopsis
- Complete surgical resection with negative margins is crucial for treating rectal cancer, but local recurrence can be challenging; a new surgical technique was developed to resect the pubic arch and ischial bone for recurrent cases.
- A case study demonstrated this technique on a patient with a fourth local recurrence where the tumor invaded the pubic arch; an osteotomy successfully removed the affected bones while ensuring no cancer cells were present in the margins.
- This innovative approach may significantly aid in achieving complete resection in patients with recurrent rectal cancer, improving treatment outcomes.
Aim: This multicenter retrospective study aimed to clarify the surgical and oncological outcomes of patients with high-grade soft tissue sarcoma (STS) who underwent prosthetic replacement reconstruction after lower extremity tumor resection.
Patients And Methods: We retrospectively collected the data of 27 patients with high-grade STS. The mean follow-up duration after prosthetic replacement was 44.
Article Synopsis
- Malignant peripheral nerve sheath tumors (MPNSTs) are uncommon soft-tissue tumors, with brain metastasis being rare.
- The study details two case reports: a 73-year-old male with brain metastasis and a 32-year-old male with leptomeningeal metastasis from MPNSTs, along with a review of 41 additional cases.
- Different clinical courses and treatment strategies are necessary for brain and leptomeningeal metastases of MPNSTs, highlighting the importance of tailored approaches in patient care.
Article Synopsis
- Tumor-devitalized autografts are biological reconstruction methods used after tumor excision in aggressive bone or soft tissue tumors, providing benefits like no disease transmission risk and better fit for the implant site, but they also have limitations including reduced healing potential and biomechanical strength.
- The study aimed to investigate rates of complications (like fracture and infection), 5-year and 10-year graft survival, union rates of the graft-host junction, and overall limb function related to these autografts.
- Conducted as a retrospective study across 26 sarcoma centers in Japan, the research analyzed data from 494 patients over a 25-year period, focusing on the outcomes and factors affecting the effectiveness of these treatments.
Article Synopsis
- Reconstruction after periacetabular bone tumor removal poses challenges between using large bone grafts or implants for walking function and opting for hip transposition, which has less risk but variable results.
- The study aims to assess recovery time for walking function after hip transposition, identify factors influencing early recovery, and examine if quick recovery correlates with improved walking ability and higher MSTS scores.
- A retrospective review included 48 patients over a decade, focusing on those treated with hip transposition, with 38 patients monitored for at least 6 months to evaluate their functional recovery post-surgery.
Article Synopsis
- Soft tissue sarcomas (STS) are rare cancers treated mainly with doxorubicin-based chemotherapy as the first line, and various drugs like trabectedin, eribulin, and pazopanib are considered for second-line treatment, with no clear evidence supporting one over the others.
- The JCOG1802 study is a randomized phase II trial aimed at comparing the effectiveness of trabectedin, eribulin, and pazopanib in patients with advanced STS who have not responded to initial doxorubicin treatment.
- The study’s primary goal is to evaluate progression-free survival, while secondary goals assess overall survival and other relevant treatment outcomes in eligible participants aged 16 and older with specific STS diagnoses.
Article Synopsis
- This study examines the link between the age at which patients have surgery for head and neck sarcoma and their survival outcomes.
- It involved 26 patients treated surgically between 2003 and 2017, finding that older patients (≥55 years) generally had poorer survival rates.
- The results indicate that older age is a significant predictor of worse overall survival in these patients, especially if they did not receive chemotherapy.
Article Synopsis
- Affinos, a bone substitute made of β-tricalcium phosphate with a special porous structure, was evaluated for its effectiveness in healing bone defects among 56 patients by comparing two groups based on the type of bone involved.
- The study found that both the resorption of Affinos and trabeculation (the formation of new bone) improved over time, with significant correlations indicating that early changes in these parameters could predict long-term healing outcomes.
- Key findings suggest that smaller defect sizes and higher resorption rates shortly after surgery were linked to better long-term healing in both groups, and specific bone metabolic markers were also assessed to enhance understanding of the healing process.
Article Synopsis
- - The study examined the surgical outcomes of total pelvic exenteration combined with sacral resection for rectal cancer, focusing on how the level of sacral resection affects short-term results.
- - Data from 20 cases indicated that patients with recurrent cancers experienced significantly higher complication rates, particularly with "Upper" sacral resections compared to "Lower" resections.
- - The findings suggest that patients undergoing "Upper" sacral resections for recurrent rectal cancer are at a greater risk for complications, emphasizing the necessity for careful postoperative monitoring.
Article Synopsis
- This study analyzed the effectiveness of two chemotherapy regimens in high-risk soft tissue sarcoma patients: gemcitabine plus docetaxel (GD) versus the standard Adriamycin plus ifosfamide (AI).
- Results showed that after treatment, the estimated 3-year overall survival was 91.4% for AI compared to 79.2% for GD, indicating that GD was not as effective as AI.
- Despite GD having milder side effects, it should not be adopted as a standard treatment for this type of cancer, as per the findings from the trial.
Article Synopsis
- Aseptic loosening of cemented stems has led to the development of the Kyocera Modular Limb Salvage System (KMLS) cementless stems by the Japanese Musculoskeletal Oncology Group, aiming to improve outcomes for endoprosthetic reconstruction despite challenges like stem breakage and stress shielding.
- A study was conducted on 100 patients with KMLS stems to evaluate prosthesis survival, complications, and functional outcomes, revealing that 88.2% survived at 2 years and 79.6% at 4 years, with younger age linked to poorer survival rates.
- Complications occurred in 31 patients, with 13 requiring revision surgery, and the average functional score at 1 year was
Article Synopsis
- This study analyzed the clinical outcomes of 187 patients with pelvic and retroperitoneal bone and soft tissue sarcoma (BSTS) treated at specialized centers in Japan.
- The 3-year overall survival (OS) rate was 71.7%, while local control (LC) and progression-free survival (PFS) rates were 79.1% and 48.6%, respectively, with osteosarcoma showing significantly worse outcomes.
- Key poor prognostic factors identified included larger tumor size, soft tissue tumors, presence of distant metastasis, and age, impacting overall survival, local control, and progression-free survival.
Article Synopsis
- * The study included 62 patients with DDCS and 19 with G3CS, revealing that R0 resection was achieved in the majority of cases and highlighting that the 5-year disease-specific survival (DSS) was 18.5% for DDCS and 41.7% for G3CS.
- * Key factors influencing prognosis included stage and treatment type, with poor overall survival indicating a need for more effective chemotherapy options
Article Synopsis
- The JCOG1610 trial aimed to compare preoperative denosumab treatment to curettage with local therapy for patients with giant cell tumor of bone, focusing on relapse-free survival as the main outcome.
- Patient enrollment started in October 2017 but was halted in December 2020 due to low participant numbers, with only 18 patients registered across 13 institutions at that time.
- Results indicated that preoperative denosumab did not show superiority over the traditional method in preventing tumor relapse, with similar relapse-free survival rates observed in both treatment groups after one and two years.
Article Synopsis
- - The guidelines aim to provide evidence-based recommendations for improving the diagnosis, treatment, and prognosis of patients with soft tissue tumors.
- - A multidisciplinary team created 22 clinical questions (CQs) and developed guidelines based on systematic reviews of evidence and expert input, following specific development methods.
- - The recommendations are designed to help healthcare professionals make better decisions in treating soft tissue tumors, ultimately enhancing patient care in this area.
Article Synopsis
- The distal femur is a frequent location for bone tumors, and surgical resection followed by prosthetic replacement is a common treatment method.
- A study involving 125 patients treated between 1998 and 2014 found that the Kyocera Modular Limb Salvage (KMLS) systems showed long-term effectiveness, with a mean follow-up of over 11 years.
- However, results indicated significant issues, including high rates of additional surgeries and implant failure, particularly related to stem breakage and aseptic loosening, highlighting the need for careful monitoring and consideration of implant type.
Factors Affecting Delay in Initial Treatment of Patients with Soft Tissue Sarcomas.
J Hand Surg Asian Pac Vol
February 2022
Article Synopsis
- This study investigates the delays in initial treatment for soft tissue sarcomas (STS), which are rare, by analyzing 134 patient records from Oct 2009 to Mar 2019.
- The average delay before treatment onset was 9.9 months, with patients having upper extremity tumors experiencing shorter delays (7.9 months) compared to those with tumors in other locations.
- Factors contributing to treatment delays included a history of diabetes and smoking, suggesting that these might indicate a lower prioritization of health among patients.
Article Synopsis
- This systematic review investigated the effectiveness of marginal resection versus wide resection in patients with atypical lipomatous tumors (ALT), focusing on local recurrence rates, overall survival, and adverse events from 1990 to 2019.
- The analysis of six studies found that marginal resection had a local recurrence rate of 14.2%, while wide resection had 1.4%, with no significant survival differences but a lower rate of adverse events in the marginal resection group.
- The study concluded that, given the generally favorable prognosis for ALT, marginal resection can be an acceptable option as it helps preserve musculoskeletal function despite a higher recurrence risk compared to wide resection.
Article Synopsis
- This study examined the outcomes of lung metastasectomy and radiofrequency ablation (RFA) in 92 patients with soft tissue sarcoma (STS) across nine institutions.
- The cohort consisted of 65 men and 27 women, with a mean age of 59, and the average follow-up period was 51 months.
- Results showed a 5-year post-metastatic survival rate of 52%, with better outcomes for patients who received complete treatment, especially those with smaller and single lung metastases.
Article Synopsis
- Denosumab is a medication used to treat a type of bone tumor called giant cell tumor of bone (GCTB), especially when surgery is difficult or to help make surgery easier.
- There are no clear guidelines on how to use denosumab before surgery, and some cases have come back even after surgery.
- The text shares a specific case of a serious GCTB where the tumor came back after surgery, even though denosumab was used before the operation.
Article Synopsis
- The study focuses on reconstructing the extensor mechanism in patients who had proximal tibia mega-prosthetic replacements due to aggressive bone tumors since 2006.
- Fourteen patients were treated by wrapping and suturing the reversed iliotibial band around the tibia, with function assessed through extensor lag, knee flexion, and a scoring system.
- Results showed minimal extensor lag and decent knee flexion, with some correlation between knee flexion and patellar height, indicating that this surgical technique provides positive functional outcomes despite some complications.
Article Synopsis
- Osteochondral destruction and high recurrence rates post-surgery are significant challenges in treating tenosynovial giant cell tumors, prompting a study of 80 surgically treated patients with intra-articular tumors.
- The study found a 5-year local recurrence-free survival rate of 71.4%, with diffuse tumor type and knee location identified as key risk factors for recurrence and destruction.
- Additionally, local recurrence is associated with greater chances of osteochondral destruction, highlighting the importance of tumor type and location in managing these tumors.
Article Synopsis
- Several types of soft tissue sarcomas exhibit infiltrative growth known as tail-like lesions, which can affect treatment outcomes.
- A study of 36 patients from 2012 to 2019 examined the impact of neoadjuvant therapy (chemotherapy and/or radiotherapy) on these lesions, finding that the median length of the lesions decreased significantly during treatment.
- The shrinkage of the tail-like lesions did not correlate with better surgical margins or improved oncologic outcomes, suggesting a need for further research to refine surgical strategies.