Adaptation and dosimetric commissioning of a synchrotron-based proton beamline for FLASH experiments.

. Irradiation with ultra-high dose rates (>40 Gy s), also known as FLASH irradiation, has the potential to shift the paradigm of radiation therapy because of its reduced toxicity to normal tissues compared to that of conventional irradiations. The goal of this study was to (1) achieve FLASH irradiation conditions suitable for pre-clinicalandbiology experiments using our synchrotron-based proton beamline and (2) commission the FLASH irradiation conditions achieved.