Lactate dehydrogenase enhances immunoglobulin production by human hybridoma and human peripheral blood lymphocytes.

Lactate dehydrogenase (LDH) derived from rabbit muscle enhanced IgM production by human-human hybridoma HB4C5 cells 12.4-fold at 320 mug/ml under serum-free conditions. LDHs from pig muscle and pig heart also accelerated IgM production 8.