Publications by authors named "Satoshi Shiono"

Background: Mature teratomas are benign cystic tumors that are most commonly asymptomatic. However, in some cases, mediastinal teratomas rupture the lungs and mediastinum with potentially fatal outcomes. Herein, we report a case of a large mediastinal mature teratoma that expanded to the entire left hemithorax in a child with common cold-like symptoms.

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  • - The study examined the role of programmed cell death-ligand 1 (PD-L1) expression and epidermal growth factor receptor (EGFR) mutations as biomarkers for lung adenocarcinoma, analyzing data from 847 patients across 21 centers in Japan from 2015 to 2018.
  • - Results showed that while PD-L1 expression was linked to shorter recurrence-free survival (RFS) in both EGFR-mutant and wild-type patients, it had no effect on overall survival (OS) in EGFR-mutant patients.
  • - The findings suggest that PD-L1 expression is a poor predictor of OS for EGFR-mutant patients and does not influence the effectiveness of post-relapse treatment with EGFR-
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  • The neoDRATS technique is a new method in robotic-assisted thoracic surgery that uses four robotic arms independently, reducing the need for skilled assistants during procedures.
  • Patients undergo surgery while positioned laterally under general anesthesia, using the da Vinci Xi Surgical System with specific setups for each side.
  • The results show that neoDRATS leads to successful surgeries with less postoperative discomfort and smoother operations, making it a promising alternative for facilities with limited access to skilled surgical assistants.
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In patients with non-small cell lung cancer (NSCLC) who present with radiologically undetermined malignant pleural dissemination or incidental surgical diagnosis of the same, surgery is generally not the preferred option; systemic therapy is favoured. However, there is no consensus on incorporating primary site resection into the treatment plan. Retrospective analyses hint at potential benefits of combining systemic therapy with primary site resection, but prospective studies have yet to confirm these findings.

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Objectives: The clinical trial showed that sublobar resection was not inferior to lobectomy in terms of disease-free survival in patients with peripherally located non-small-cell lung cancer ≤2 cm. However, it is not clear whether sublobar resection is indicated for all types of c-stage IA lung cancer. The purpose of this study was to clarify whether sublobar resection is indicated for c-stage IA hypermetabolic lung cancer.

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This single-arm multi-institutional prospective study aimed to evaluate the 10-year outcomes of sublobar resection for small-sized ground-glass opacity-dominant lung cancer. Among 73 patients prospectively enrolled from 13 institutions between November 2006 and April 2012, 53 ground-glass opacity-dominant lung cancer patients underwent sublobar resection with wedge resection as the first choice. The inclusion criteria were maximum tumor size of 8-20 mm; ≥ 80% ground-glass opacity ratio on high-resolution computed tomography; lower F-fluorodeoxyglucose accumulation than the mediastinum; intraoperative pathological diagnosis of adenocarcinoma in situ; and no cancer cells on intraoperative cut margins.

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  • The study compares survival rates between two surgical procedures—segmentectomy and wedge resection—for patients with early-stage non-small cell lung cancer (cT1cN0M0).
  • A total of 91 patients were analyzed, showing no significant difference in overall survival after 5 years (67.7% for segmentectomy vs 52.0% for wedge resection), but a notably worse recurrence-free survival for the wedge resection group (46.9% vs 66.6%).
  • The findings suggest that while both surgeries have similar overall survival rates, segmentectomy may offer a better prognosis in terms of recurrence-free survival.
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  • The focus of postoperative monitoring for patients with non-small cell lung cancer is to identify any recurrence or new cancers while treatments are still effective.
  • Although guidelines suggest regular CT scans, evidence shows they may not actually improve patient survival, particularly in advanced stages of the disease.
  • A new phase III trial starting in October 2022 aims to test the effectiveness of less frequent CT scans compared to standard monitoring, involving 1100 patients across 45 institutions over four years, with overall survival as the main goal.
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Background: Benign mature teratomas are the most common type of anterior mediastinal germ cell tumor. Mature intrapericardial teratomas are generally diagnosed during infancy because of symptoms of cardiac compression. In contrast, mature adult intrapericardial teratomas are extremely rare, accounting for less than 1% of mature intrapericardial teratomas.

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Objective: This study investigates Japanese gay and bisexual men's experiences of seeking help for emotional support from others regarding their sexual orientation concerns. It examines the relationship between their help-seeking and presence of gay and bisexual peers, duration between questioning their sexual orientation and accepting it, and experience of coming out to family members by multiple logistic regression analysis.

Results: We conducted a cross-sectional survey using a self-reported paper questionnaire.

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Background: Lung segment anatomy is complex and difficult for medical students to comprehend, so education is a challenging issue. Three-dimensional (3D) models may be a more effective teaching tool for medical students. We evaluated the usefulness of 3D models in education for segmentectomy.

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  • - The study analyzed the effects of central nervous system (CNS) metastasis on performance status, treatment responses, and survival rates in lung adenocarcinoma patients with common EGFR mutations following surgical resection.
  • - Out of 4181 patients, 78 experienced CNS metastasis, which was more common in those receiving conventional adjuvant chemotherapy; however, this treatment showed no significant benefits in relapse-free survival or overall survival post-relapse.
  • - The findings suggest that CNS metastasis doesn't noticeably impact performance status or alter treatment efficacy with EGFR-tyrosine kinase inhibitors, indicating a need for more studies on managing CNS metastasis in the context of adjuvant TKI therapies.
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Purpose: Saliva is often used as a tool for identifying systemic diseases because of the noninvasive nature of its collection. Moreover, salivary metabolites can be potential predictive factors for postoperative survival. We conducted the present study to establish whether salivary metabolites can function as predictive biomarkers for lung surgery complications.

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Background: The ADAURA trial reported that osimertinib improved overall survival (OS) as an adjuvant chemotherapy for pathological stage IB-IIIA epidermal growth factor receptor (EGFR) mutant lung cancer compared with a placebo. Currently, platinum-based adjuvant chemotherapy is the standard treatment for patients with or without EGFR mutations. This study aimed to evaluate the efficacy of platinum-based adjuvant chemotherapy in patient with stage II-IIIA EGFR mutant lung adenocarcinoma.

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Background: Robotic-assisted thoracic surgery (RATS) has gained increasing interest in recent years, with most procedures performed using the conventional multiportal approach. Uniportal RATS (URATS) approaches have recently been reported in the pursuit of minimally invasive procedures. However, URATS requires specific skills.

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Purpose: The purpose of this study is to identify the clinical, genomic, and transcriptomic features of patients with lung adenocarcinoma (LUAD) harboring uncommon epidermal growth factor receptor (EGFR) mutations (UCM) compared with common EGFR mutations (CM).

Materials And Methods: In this multicenter retrospective cohort study, clinicopathological data were collected from 1047 consecutive patients who underwent complete surgical resection for LUAD, as well as EGFR mutation analysis, between 2005 and 2012 at 4 institutions. Differences in postoperative overall survival (OS) and recurrence-free survival (RFS) according to EGFR mutation status were evaluated.

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Objectives: Third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors were recently reported to be effective as adjuvant therapy for resected lung adenocarcinoma (ADC) harbouring common EGFR mutations. However, whether the EGFR mutation is a direct risk factor for postoperative recurrence remains unknown. Therefore, we conducted a multi-institutional observational study to compare postoperative survival according to EGFR mutation status.

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Objectives In response to the steady rise in the number of cases of mpox in nonendemic countries, starting with an outbreak in the United Kingdom in May 2022, the World Health Organization declared a public health emergency of international concern on July 23, 2022. As of November 13, 2022, seven cases of mpox have been reported in Japan.Methods A community engagement approach was applied to prevent the spread of mpox in Japan.

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Background: Thoracoscopic anatomical individual basilar segmentectomy remains challenging owing to the deep intraparenchymal location of the hilar structures and anatomical variations. We analyzed and reported the experience and progress of thoracoscopic anatomical individual basilar segmentectomy at our university hospital.

Methods: We retrospectively examined the patients who underwent anatomical basilar segmentectomy at our institution from January 2004 to December 2021.

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  • The study aimed to evaluate how daily living activities (ADL) deteriorate in elderly patients (75+) after surgery for non-small cell lung cancer (NSCLC) and identify factors that predict this decline.
  • Out of 986 screened patients, 876 were eligible, with 85.1% reporting no significant deterioration in ADL after 6 months, while 11.4% showed notable decline; social activities were particularly affected.
  • Factors linked to ADL deterioration included poor health status, low geriatric screening scores, the type of surgical procedure, and surgery duration, with 22.1% of patients indicating a decrease in quality of life post-surgery.
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Background: Tumor volume doubling time (VDT) has been shown to predict prognosis in various non-small cell lung carcinoma with scant evidence for lung squamous cell carcinoma (SCC). The purpose of this study was to investigate the prognostic value of tumor VDT in resected lung SCCs.

Methods: In this study, subjects were 51 patients who underwent lobectomy for clinical stage I SCC of the peripheral lung at our institution between January 2006 and April 2020.

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Since the early 1990s, minimally invasive surgery has been introduced in many surgical fields. The progress of technology and increased interest in minimally invasive surgery has led to innovation from surgery with a large incision to complete thoracoscopic surgery in many facilities. We started thoracoscopic mediastinal surgery in 1997 and robot-assisted mediastinal surgery in 2021.

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Purpose: To determine a recommended dose of liposomal eribulin (E7389-LF) in combination with nivolumab in patients with advanced solid tumors, and to evaluate the safety, efficacy, pharmacokinetics, and biomarker impact of this regimen.

Experimental Design: Japanese patients with advanced, nonresectable, or recurrent solid tumors and no existing alternative standard/effective therapy (except nivolumab monotherapy) were assigned to either E7389-LF 1.7 mg/m plus nivolumab 360 mg every 3 weeks, E7389-LF 2.

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Background: Immune checkpoint inhibitors (ICIs) have been shown to prolong the survival of patients with non-small cell lung cancer (NSCLC) and have allowed complete resection for advanced lung cancer. However, immune-related adverse events (irAEs) have been recognized as concerning side effects of ICIs.

Case Presentation: A 62-year-old man visited our hospital because of fever, dyspnea, and anorexia.

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Objectives: Residual middle lobectomy after upper lobectomy and lower lobectomy differs in their indications and perioperative outcomes. Therefore, we aimed to evaluate the indications and perioperative outcomes of residual middle lobectomy after upper and lower lobectomy.

Methods: The data of 14 patients who underwent residual middle lobectomy after upper or lower lobectomy between January 1997 and December 2021 were extracted and analyzed.

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