Publications by authors named "Satoshi Saijoh"
RNAs, such as noncoding RNA, microRNA, and recently mRNA, have been recognized as signal transduction molecules. CD271, also known as nerve growth factor receptor, has a critical role in cancer, although the precise mechanism is still unclear. Here, we show that CD271 mRNA, but not CD271 protein, facilitates spheroid cell proliferation.
View Article and Find Full Text PDFCD271 (also referred to as nerve growth factor receptor or p75) is expressed on cancer stem cells in hypopharyngeal cancer (HPC) and regulates cell proliferation. Because elevated expression of CD271 increases cancer malignancy and correlates with poor prognosis, CD271 could be a promising therapeutic target; however, little is known about the induction of CD271 expression and especially its promoter activity. In this study, we screened transcription factors and found that RELA (p65), a subunit of nuclear factor kappaB (NF-κB), is critical for CD271 transcription in cancer cells.
View Article and Find Full Text PDFArticle Synopsis
- Cancer stem cells (CSCs) are linked to cancer recurrence and metastasis, with BEX2 being a gene associated with chemotherapy resistance in dormant CSCs.
- A study screened 9,600 small chemical compounds to find inhibitors of BEX2 expression and discovered BMPP, a compound that reduces BEX2 expression and enhances chemotherapy sensitivity in cholangiocarcinoma cells.
- The results suggest that BMPP could be a promising candidate for developing new cancer treatments targeting CSCs that overexpress BEX2.
[Assessment of Cachexia in Head and Neck Cancer Patients Based on a Modified Glasgow Prognostic Score].
Nihon Jibiinkoka Gakkai Kaiho
February 2016
We retrospectively analyzed 54 patients who died of head and neck squamous cell caricinoma regarding the process and duration of cachexia using the modified Glasgow Prognostic Score (mGPS). The patients were classified as having cachexia when the serum albumin level was less than 3.5 mg/dL and the C-reactive protein (CRP) level was more than 0.
View Article and Find Full Text PDFObjectives/hypothesis: In order to make possible organ preservation, since 2007 our hospital has performed induction chemotherapy (ICT) with cisplatin and 5-fluorouracil (PF) for hypopharyngeal cancer as chemoselection, followed by alternating chemoradiotherapy (ACRT) with docetaxel, cisplatin, and 5-fluorouracil in (TPF) good responders and curative surgery was used in poor responders.
Methods: Twenty-six patients with stage III to stage IVB hypopharyngeal cancer received ICT. Eleven of the patients were classified as poor responders and received curative surgery.