Understanding paleo-earthquakes in the Kuril Trench based on Late-Holocene tsunami deposits in the distal region from wave sources, northern Hidaka, Hokkaido, Japan.

Geological evidence, such as tsunami deposits, is crucial for studying the largest rupture zone of the Kuril Trench in Hokkaido, Japan, due to its poor historical record. Although 17th-century tsunami deposits are widely distributed across Hokkaido, the presence of multiple wave sources during that period, including the collapse of Mt. Komagatake, complicates the correlation with their wave sources.

Creation of the first regional medical resource map for use in a disaster.

Background: Japan is located on the Pacific Ring of Fire and experiences frequent earthquakes. In addition, as the climate is changing due to global warming, heavy rains have caused frequent floods recently. Following the occurrence of disasters, citizens often experience confusion regarding access to healthcare services.

Students' perception of problem-based learning at a Japanese medical school: an exploratory sequential mixed method.

Objectives: This study aimed to assess the perception of PBL among Japanese medical students.

Methods: Learning effects and challenges of PBL from the students' viewpoint were assessed with an exploratory sequential mixed method. Focus group discussions followed by thematic analysis were conducted with 27 students and residents.

Changes of cancer diagnosis disclosure to children in Japan in the last 20 years.

Background: The practice of cancer diagnosis disclosure to children has been changed with the times. The regulations of clinical trials in the 2000s might change the practice in Japan. However, the perspective of this topic among children and adults has not been investigated in detail.

Change in children's perception of cancer in the last 10 years in Japan.

Background: Social awareness of cancer can be changed with cancer education and proper distribution of cancer information. This study addressed the current situation and historical changes to children's perception of cancer.

Methods: Questionnaire surveys were conducted among healthy school children aged 10-15 years in 2008 and 2018.

A dataset for distribution and characteristics of Holocene pyroclastic fall deposits along the Pacific coasts in western Hokkaido, Japan.

The tephra layers known with eruption ages play an important role in an investigation of tsunami history and archaeology in addition to volcanic history in Hokkaido, Japan. We investigated the event and tephra layers of the Late Holocene in the Pacific coast of western Hokkaido, where the stratigraphy of the Late Holocene has not been clarified. Surveys in coastal peatlands, mostly undisturbed deposits, have allowed for the discovery of thin tephra layers.

Close interaction with bone marrow mesenchymal stromal cells induces the development of cancer stem cell-like immunophenotype in B cell precursor acute lymphoblastic leukemia cells.

Minimal residual disease of leukemia may reside in the bone marrow (BM) microenvironment and escape the effects of chemotherapeutic agents. This study investigated interactions between B cell precursor (BCP)-acute lymphoblastic leukemia (ALL) cells and BM mesenchymal stromal cells (BM-MSCs) in vitro. Five BCP-ALL cell lines established from pediatric patients and primary samples from a BCP-ALL patient were examined by flow cytometry and immunocytochemistry for expression of specific cell surface markers and cell adhesion proteins.

Social defeat stress induces phosphorylation of extracellular signal-regulated kinase in the leptomeninges in mice.

Aims: Animal studies using various stress models have shown that excessive environmental stress induces depression? and anxiety?like behaviors through inflammatory responses in the brain and periphery. Although the leptomeningeal cells have multiple functions related to inflammatory responses in the brain, whether environmental stress influences the leptomeninges remains unknown. In this study, we aimed to examine phosphorylation of the extracellular signal-regulated kinase (ERK) in the leptomeninges.

Functional characterization of hematopoietic stem cells in the spleen.

Objective: Hematopoietic stem cells (HSCs) reside in both bone marrow (BM) and spleen in adult mice. However, whether BM and spleen HSCs are functionally similar is not known. Spleen HSCs were compared with BM HSCs by various assays.

Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.

The nature of the in vivo cellular events underlying thrombus formation mediated by platelet activation remains unclear because of the absence of a modality for analysis. Lymphocyte adaptor protein (Lnk; also known as Sh2b3) is an adaptor protein that inhibits thrombopoietin-mediated signaling, and as a result, megakaryocyte and platelet counts are elevated in Lnk-/- mice. Here we describe an unanticipated role for Lnk in stabilizing thrombus formation and clarify the activities of Lnk in platelets transduced through integrin alphaIIbbeta3-mediated outside-in signaling.