Contact Dermatitis after Prescription of an Ophthalmic Ointment Containing Fradiomycin Sulfate: A Retrospective Database Study Using Japanese Health Insurance Claims Data.

Background: Topical ointments containing fradiomycin sulfate, such as fradiomycin sulfate/methylprednisolone (F/M) and fradiomycin sulfate/betamethasone sodium phosphate (F/B), are known to cause allergic contact dermatitis (CD) in some patients, especially when used for the periocular region. F/M is commonly prescribed to patients for various conditions; however, there are no reports with respect to the incidence of CD caused by F/M in actual practice.

Objective: The aim was to investigate the incidence of CD using a data-based retrospective cohort study.

A retrospective, cross-sectional study of real-world values of cardiovascular risk factors using a healthcare database in Japan.

Background: Data collected by the Japanese Ministry of Health, Labour and Welfare (MHLW), namely data from the Specific Health Checkups and Specific Health Guidance (MHLW-SH) and the National Health and Nutrition Survey (MHLW-H&N) allow assessment of blood pressure (BP), low-density lipoprotein cholesterol (LDL-C), and hemoglobin A1c (HbA1c) in Japan. Recently, a large database of employment-based health insurance has been developed by MinaCare Co. Ltd.

Nonlinear optical properties of gold nanoparticles selectively introduced into the periodic microdomains of block copolymers.

Nonlinear-optical nanocomposite materials with a photonic crystal structure were fabricated using block copolymers and gold nanoparticles. By dispersing the gold nanoparticles into the selective microdomains of the block copolymers, we could achieve the enhancement of nonlinear optical properties as revealed by the Z-scan technique. The optical nonlinearities were enhanced by the local field effect and the effect of the periodic distribution of the microdomains filled with gold nanoparticles.