Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway.

Cigarette smoking is a well-known risk factor inducing the development and progression of various diseases. Nicotine (NIC) is the major constituent of cigarette smoke. However, knowledge of the mechanism underlying the NIC-regulated stem cell functions is limited.

SIRT1 Controls Enteroendocrine Progenitor Cell Proliferation in High-Fat Diet-Fed Mice.

Background & Aims: We aimed to investigate how sirtuin 1 (SIRT1), a conserved mammalian Nicotinamide adenine dinucleotide-dependent protein deacetylase, regulates the number of enteroendocrine cells (EECs). EECs benefit metabolism, and their increase potentially could treat type 2 diabetes and obesity.

Methods: We used mice with specific Sirt1 disruption in the intestinal epithelium (VilKO, villin-Cre, and Sirt1 mice) or enteroendocrine progenitor cells (EEPCs) (NgnKO, neurogenin 3-Cre, Sirt1 mice) and mice with increased SIRT1 activity owing to overexpression (Sir2d mice) or 24-hour fasting.

Src kinase-associated phosphoprotein2 expression is associated with poor prognosis in non-small cell lung cancer.

Background/aim: Non-small cell lung cancer (NSCLC) is among the leading causes of cancer-related deaths worldwide. In certain human cancer types, Src is associated with cancer progression and refractory cancer. To improve the prognoses of NSCLC patients, we evaluated Src kinase-associated phosphoprotein 2 (SKAP2), a factor associated with integrin-stimulated cytoskeletal rearrangement, as a new therapeutic target.