Relationships between oxygen and glucose metabolism in human liver tumours: positron emission tomography using (15)O and (18)F-deoxyglucose.

Background: Recently, investigators have measured glucose utilization in liver tumours using F-deoxyglucose positron emission tomography (FDG PET) in order to characterize tumours and predict therapeutic effects. However, the detectability of liver tumours by this method remains unclear. In addition, no study has examined the association between oxygen and glucose metabolism in liver tumours using PET.

Changes in hepatic parenchymal blood flow with colorectal metastases: increase in arterial and decrease in portal blood flow.

Background/aims: We investigated the changes in arterial and portal blood flow in the non-tumorous liver parenchyma in the presence of colorectal hepatic metastases using the H(2)15O dynamic positron emission tomography method.

Methodology: Thirty-eight patients were classified into colorectal hepatic metastases (MET), hemangioma (HEM), and no liver tumor (NR) groups. We quantitatively measured arterial blood flow and portal blood flow in each anatomical segment of the non-tumorous liver parenchyma.

Quantitative measurement of regional blood flow in hepatic focal nodular hyperplasia. Findings on positron emission tomography.

The blood flow through normal liver parenchyma and a pathologically proven hepatic region of focal nodular hyperplasia (FNH) of the lateral lobe, was measured in a single patient in a quantitative manner using regional dynamic positron emission tomography (PET) imaging with O-15 carbon dioxide (steady state) and O-15 water (dynamic state). The steady state PET images revealed higher radioactivity concentration in the lateral lobe than in the surrounding normal liver parenchyma. Regional and total blood flow in the region of FNH, as determined by the dynamic state method, was 292.

Differential diagnosis of gallbladder cancer using positron emission tomography with fluorine-18-labeled fluoro-deoxyglucose (FDG-PET).

Background And Objectives: The purpose of this paper is to evaluate the utility of positron emission tomography (PET) with fluorine-18-labeled fluoro-deoxyglucose (FDG) in the preoperative differential diagnosis of gallbladder tumors. We performed PET studies of gallbladder tumors in order to predict the malignancy of these tumors preoperatively.

Methods: Sixteen patients who had protuberant lesions in the gallbladder and who were scheduled to undergo surgery were studied with PET using FDG.