Publications by authors named "Satoshi Kubota"

Background: Nursing home residents engage in lower levels of physical activity, primarily remaining seated or lying down, except for routine activities of daily living (ADLs). Since ADLs, particularly toileting, require effort. This study investigated the relationship between physical activity and toileting activity during the daytime among older nursing home residents.

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Background: Anemia in patients with cancer negatively affects their quality of life and cancer outcomes. However, most patients with chemotherapy-induced anemia (CIA) are not appropriately evaluated or treated, and the prevalence of iron deficiency anemia (IDA) in CIA remains unclear.

Methods: We retrospectively reviewed the electronic records of patients with gynecological cancer in two tertiary hospitals, between March 2023 and July 2023, and evaluated their anemia status.

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Objectives: Salivary gland cancer is a rare disease composed of more than 20 histological types with different grades of malignancy. The aim of this multicenter, retrospective study was to identify the most important predictors affecting recurrence and survival after surgery.

Material And Methods: A total of 543 patients with salivary gland cancers that underwent curative surgery between 2012 and 2022 in 13 institutions in northern Japan were evaluated in this study.

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Heat stress (HS) severely compromises intestinal barrier function in poultry, resulting in significant production losses. This study aimed to explore the molecular response of the small intestine to acute HS in breeder hens. Fifty 28-week-old breeder hens were raised individually in a cage and randomly assigned to control and heat-treated groups (25 hens each).

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The high specificity of the human skin microbiome is expected to provide a new marker for personal identification. Metagenomic sequencing of clustered regularly interspaced short palindromic repeats (CRISPRs), which we call metaCRISPR typing, was shown to achieve personal identification accurately. However, the intra-individual variability observed in previous studies, which may be due to poor DNA yields from skin samples, has resulted in non-reproducible results.

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Introduction: We analyzed the time course of postvoid residual urine volume for patients with cerebrovascular diseases in the acute phase.

Materials And Methods: A multidisciplinary specialized team measured postvoid residual urine volume of 65 patients (31 patients with cerebral infarction and 34 patients with cerebral hemorrhage) from September 2021 to August 2023. If a patient's postvoid residual urine volume was 100 mL or more, an indwelling urinary catheter was reinserted with or without medication, or clean intermittent catheterization was performed with or without medication.

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  • Recent advancements in chemotherapy have improved survival rates for head and neck cancer patients, leading to the development of totally implantable venous access devices for chemotherapy use.
  • A study investigated 210 patients who had these devices implanted in their upper arms over a decade, examining their effectiveness for treatment and any associated adverse events.
  • The results showed a low adverse event rate, with certain factors like non-ultrasound-guided puncture increasing risks, suggesting that using ultrasound guidance may enhance safety in these procedures.*
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Objective: This study aimed to find global mechanisms related to carnosine synthesis in slow-growing Korat chickens (KRC) using a proteomic approach.

Methods: M. pectoralis major samples were collected from 10-week-old female KRC including low-carnosine (LC, 2,756.

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  • * Researchers conducted a study on Korat chickens to analyze gene expressions in the jejunum after providing these supplements, identifying 407 differentially expressed genes related to their absorption and transportation.
  • * The study highlighted 6 key genes linked to relevant biological pathways, providing potential insights for enhancing carnosine content in chicken meat and identifying molecular markers for future improvements.
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  • A study was conducted on the MiniMed 770G hybrid closed-loop (HCL) system to evaluate its impact on glycemic control in Japanese individuals with type 1 diabetes over a 24-week period.
  • Results showed a significant increase in time spent within the target glucose range (70-180 mg/dL) and a decrease in overall glycated hemoglobin levels, indicating better diabetes management.
  • Despite improvements in glycemic metrics, patient-reported outcomes regarding treatment burden, satisfaction, and quality of life remained unchanged, suggesting that while the system is effective, it did not impact the patients' perceived experience.
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Gastric metastasis of renal cell carcinoma (RCC) is rarely encountered. The time interval between the primary diagnosis of RCC and the occurrence of gastric metastasis tends to occur after more than 10 years. Clinicians should be diligent in checking the general symptoms of patients for more than 10 years.

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  • A case study discusses a rare instance of amyloid A amyloidosis in the bladder following treatment for bladder cancer in an 87-year-old man.
  • The patient experienced recurrent bladder tumors, with biopsy results indicating the presence of amyloid A, which might be linked to his existing cardiac issues.
  • The findings suggest that bladder tumor pathology can help identify systemic amyloid A amyloidosis, potentially explaining the patient's cardiac complications.
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Background: , a prized resource in Japan, plays a vital role in traditional arts and fishing industries. Because of diminished stock due to overexploitation, ongoing efforts are focused on restoration through transplantation. This study aimed to enhance our understanding of the reproductive biology of these valuable corals and find more efficient methods for sex determination, which may significantly contribute to conservation initiatives.

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S-adenosylmethionine (SAM) is considered to be a useful therapeutic agent for degenerative cartilage diseases, although its mechanism is not clear. We previously found that polyamines stimulate the expression of differentiated phenotype of chondrocytes. We also found that the cellular communication network factor 2 (CCN2) played a huge role in the proliferation and differentiation of chondrocytes.

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  • * Researchers developed organoid lines from SCNEC patients, focusing on one line that displayed mixed tumor characteristics, showing various differentiation in lab tests and animal models.
  • * Single-cell analysis showed distinct tumor cell clusters, linked to cancer markers and differentiation states; drug treatments affected marker expression, suggesting these mixed tumors share a common origin with flexible cancer cell identities.
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The slow-growing Korat chicken (KR) has been developed to provide an alternative breed for smallholder farmers in Thailand. Carnosine enrichment in the meat can distinguish KR from other chicken breeds. Therefore, our aim was to investigate the effect of enriched carnosine synthesis, obtained by the β-alanine and L-histidine precursor supplementation in the diet, on changes to metabolomic profiles and biochemical compounds in slow-growing KR jejunum tissue.

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  • Amyloidosis of the ureter is a rare condition, making it hard to differentiate from ureteral tumors.
  • A 64-year-old Japanese woman initially exhibited symptoms like blood in urine and kidney swelling in 2014, but no tumor was found.
  • By 2021, further tests led to a diagnosis of amyloid A amyloidosis after a biopsy revealed amyloid components in the ureter.
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Cellular communication network factor 2 (CCN2) molecules promote endochondral ossification and articular cartilage regeneration, and circular RNAs (circRNAs), which arise from various genes and regulate gene expression by adsorbing miRNAs, are known to be synthesized from CCN2 in human vascular endothelial cells and other types of cells. However, in chondrocytes, not only the function but also the presence of CCN2-derived circRNA remains completely unknown. In the present study, we investigated the expression and function of CCN2-derived circRNAs in chondrocytes.

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  • Saliva found at crime scenes is important forensic evidence, but existing tests struggle to differentiate it from nasal secretions.
  • Recent studies have used oral bacteria as markers to identify saliva, but their effectiveness against nasal samples needed further testing.
  • This research suggests adding the Staphylococcus gene as a marker could improve the accuracy of saliva detection tests by reducing false positives related to nasal secretion contamination.
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  • The study investigates the role of cellular communication network factor 6 (CCN6) in the invasion and metastasis of oral squamous cell carcinoma (OSCC) to bone, highlighting its suppressed production in a more aggressive cell line.
  • CCN6 works by interacting with bone morphogenetic protein 2 (BMP2) to inhibit epithelial-mesenchymal transition (EMT) and cell migration, while also affecting osteoclastogenesis through its relationship with receptor activator of nuclear factor-κB ligand (RANKL).
  • The findings indicate that while CCN6 prevents EMT in OSCC, its cooperation with BMP2 and interference with RANKL may contribute to bone metastasis, exhibiting a complex dual role
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This study proposes a strategy to manipulate the fatty acid (FA) content in slow-growing Korat chicken (KRC) meat using tuna oil (TO). To determine the optimal level and feeding period of TO supplementation, we conducted a study investigating the effects of dietary TO levels and feeding periods on meat quality, omega-3 polyunsaturated fatty acid (n-3 PUFA) composition, and gene expression related to FA metabolism in KRC breast meat. At 3 wk of age, 700 mixed-sex KRC were assigned to seven augmented factorial treatments with a completely randomized design, each consisting of four replicate pens containing 25 chickens per pen.

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Sperm storage tubules (SSTs) in the uterovaginal junction (UVJ) of the oviduct are major sites of sperm storage after artificial insemination or mating. Female birds may regulate sperm motility in the UVJ. Heat stress can decrease the reproductive ability of broiler breeder hens.

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  • A 56-year-old man diagnosed with hypertension was found to have primary aldosteronism and a 4-cm tumor on his left adrenal gland.
  • The removed adrenal gland tissue revealed both an aldosterone-producing adenoma and ectopic thyroid tissue.
  • This case marks the first documented instance of ectopic thyroid tissue in the adrenal gland coexisting with an aldosterone-producing adenoma, necessitating further studies to explore their relationship.
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  • The study explores the sex determination system of a non-bilaterian animal, Goniopora djiboutiensis, using karyotypic analysis and the identification of the dmrt1 gene.
  • Results indicated that the GddmrtC gene, linked to sperm production, is associated with a Y sex chromosome in this species, providing insight into male heterogamety.
  • This research adds to the understanding of genetic sex determination systems in non-bilaterian animals, highlighting similarities with vertebrate sex determination mechanisms.
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The Korat chicken (KR) is a slow-growing Thai chicken breed with relatively poor feed efficiency (FE) but very tasty meat with high protein and low fat contents, and a unique texture. To enhance the competitiveness of KR, its FE should be improved. However, selecting for FE has an unknown effect on meat characteristics.

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