Publications by authors named "Satoshi Hirade"
Article Synopsis
- A 64-year-old Japanese man developed sepsis and meningitis due to a Streptococcus suis infection after experiencing fever, headache, and deafness.
- His renal function deteriorated rapidly, requiring temporary hemodialysis, but improved with antimicrobial treatment following a renal biopsy.
- The case revealed similarities to staphylococcal-related nephritis, including features like mesangial proliferative nephritis and electron-dense deposits, highlighting novel findings in S. suis-associated glomerulonephritis.
Objective: In order to study the association between myocardial fibrosis and inflammatory cell infiltration in the hypertensive heart, we investigated whether N(3,4-dimethoxycinnamoyl) anthranilic acid (tranilast), an anti-inflammatory drug, would suppress myocardial fibrosis via inhibition of inflammatory cell infiltration in deoxycorticosterone-acetate (DOCA) hypertensive rats.
Methods: Sprague-Dawley rats treated with DOCA combined with the addition of 1% NaCl and 0.2% KCl in the drinking water after left nephrectomy were given tranilast (100 mg/kg per day, n = 15) or vehicle (n = 15) for up to 4 weeks.