Tacrolimus (FK506) Exhibits Fungicidal Effects against Sensu Stricto via Inducing Apoptosis.

Tacrolimus (FK506), an immunosuppressant and calcineurin inhibitor, has fungicidal effects. However, its fungicidal effect is thought to be limited to basidiomycetes, such as and , and not to ascomycetes. FK506 had no fungicidal effect on , , , , , , and (>8 µg/mL); however, was susceptible to it at low concentrations of 0.