Publications by authors named "Satoshi Fujisawa"
Masked CKD in hyperthyroidism and reversible CKD status in hypothyroidism.
Front Endocrinol (Lausanne)
November 2022
Introduction: While it is well known that thyroid function may affect kidney function, the transition of the chronic kidney disease (CKD) status before and after treatment for thyroid disorders, as well as the factors affecting this change, remains to be explored. In the present study, we focused on the change in kidney function and their affecting factors during the treatment for both hyperthyroidism and hypothyroidism.
Methods: Eighty-eight patients with hyperthyroidism and fifty-two patients with hypothyroidism were enrolled in a retrospective and longitudinal case series to analyze the changes in kidney function and their affecting factors after treatment for thyroid disorders.
Article Synopsis
- Orexin is crucial for controlling sleep, wakefulness, and feeding, and this study investigates its effects on pituitary gonadotropin regulation using mouse cells that express specific orexin receptors.
- Orexin A increases the expression of LHβ and FSHβ mRNA in a dose-dependent way, but it also suppresses gonadotropin expression induced by GnRH, while affecting the expression of GnRH receptors.
- The study reveals that orexin A influences gonadotropin expression through clock genes and interacts with BMP signaling, highlighting a complex regulatory relationship in gonadotrope cells.
Article Synopsis
- Pheochromocytomas and paragangliomas (PPGLs) are categorized into three types based on specific driver genes, with the Wnt-altered subtype being particularly aggressive and linked to gene fusions and mutations that overstimulate Wnt-β-catenin signaling.
- Wnt3a treatment in rat PC12 cells led to increased cell growth and decreased production of tyrosine hydroxylase, indicating that Wnt signaling negatively affects catecholamine biosynthesis and secretion.
- Inhibiting Wnt signaling using substances like XAV939 or sclerostin reduced cell proliferation and increased tyrosine hydroxylase levels, suggesting that enhanced Wnt-β-catenin signaling
Metal-organic frameworks (MOFs) and coordination polymers composed of thiolates as coordinating functional groups are interesting materials with unique optical and electronical properties. Herein, we report the preparation of KGF-4 and KGF-10, two Sn-MOF crystal structures with bonds between Sn and thiolate. KGF-10 was isolated as a pure phase and found to exhibit redox properties and a semiconducting band structure, as confirmed by first-principles (density functional theory) calculations.
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- * This study focuses on how orexin A influences the transcription of pro-opiomelanocortin (POMC) in mouse corticotrope AtT20 cells, showing that orexin A enhances POMC expression through upregulation of CRH receptor type-1 (CRHR1) in response to corticotropin-releasing hormone (CRH).
- * The research also indicates that orexin A does not affect POMC suppression caused by BMP-4, but it reduces Smad1/5/9
Article Synopsis
- The study investigates how orexin A affects prolactin synthesis in rat lactotrope GH3 cells, particularly focusing on its interaction with the BMP system.
- Orexin A primarily interacts with the orexin type 1 receptor (OX1R) to suppress prolactin mRNA expression and influences BMP-4's regulatory activity on prolactin production.
- The findings suggest that orexin A inhibits prolactin production by diminishing BMP activity, indicating a novel role of orexin in regulating hormone levels in lactotrope cells.
The involvement of orexins in reproductive function has been gradually uncovered. However, the functional role of orexins in ovarian steroidogenesis remains unclear. In the present study, we investigated the effects of orexin A on ovarian steroidogenesis by using rat primary granulosa cells that express both OX1 and OX2 receptors for orexins.
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- * Among the 23 patients analyzed, the findings revealed that 41.4% had adenomas and 10.3% had colon cancer, indicating a significant presence of colorectal issues.
- * Cecal intubation was successful in all patients, but those with acromegaly experienced significantly longer intubation times compared to a control group, highlighting challenges in performing colonoscopies on this demographic, particularly older patients.
The effects of melatonin on prolactin production and its regulatory mechanism remain uncertain. We investigated the regulatory role of melatonin in prolactin production using rat pituitary lactotrope GH3 cells by focusing on the bone morphogenetic protein (BMP) system. Melatonin receptor activation, induced by melatonin and its receptor agonist ramelteon, significantly suppressed basal and forskolin-induced prolactin secretion and prolactin mRNA expression in GH3 cells.
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- Osteoarthritis in the manubriosternal joint is common among patients suffering from inflammatory arthritis.
- Acromegalic arthropathy typically affects major joints like shoulders and knees, but can also cause issues in the manubriosternal joint.
- Sternalgia, or chest pain, can arise as a complication due to this involvement of the manubriosternal joint in acromegaly.