Publications by authors named "Satoshi Akuzawa"

Objectives: Sternal retractors utilized during open-heart surgeries through median sternotomy can cause upper rib fractures which sometimes further leads to brachial plexus injury. We aimed to investigate the incidence of brachial plexus injury and upper rib fractures in open-heart surgeries and how these injuries are associated with each other.

Methods: We investigated 1050 cases during the past five years.

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  • The study discusses a successful endovascular therapy using a small-diameter stent graft in a 73-year-old man with an asymptomatic pseudoaneurysm of the brachiocephalic artery.
  • The procedure involved placing an 8F sheath in the brachial artery and advancing a guidewire to the descending aorta to deliver the stent graft.
  • Final imaging showed no complications, suggesting that this minimally invasive method could be beneficial in clinical settings for treating this type of pseudoaneurysm.
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  • Acute kidney injury (AKI) can lead to end-stage kidney disease (ESKD) as a complication of aortic dissection, but typically involves evidence of renal artery obstruction, which was not present in this case.
  • A 58-year-old man with a Stanford type B aortic dissection experienced unexpected progression from AKI to ESKD despite no imaging findings of renal artery involvement.
  • After surgical intervention to address peripheral malperfusion, the patient's kidney function normalized, marking the first documented case of AKI from aortic dissection without direct renal artery blockage recovering post-surgery.
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Mediastinitis occurs after open heart surgery in a small number of cases. When it occurs, early diagnosis and treatment are important. A 69-year-old male patient suffered from mediastinitis after total aortic arch replacement.

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With the exception of myxomas, primary tumors of the heart are very rare. We present here our experience with papillary fibroelastoma in the aortic valve. We could not preserve the aortic valve because of the wide attachment of the tumor to the valve and aortic regurgitation.

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Congenital systemic-to-pulmonary artery fistulas are very rare, with the exception of congenital heart disease and pulmonary sequestration. We describe the first reported case of left internal mammary and bronchial artery to pulmonary artery fistulas associated with bilateral coronary arteries to pulmonary artery fistulas.

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Background: Our previous studies showed that transfer of hepatocyte growth factor (HGF) gene or transplantation of marrow stromal cells (MSCs) remarkably attenuated neurologic injuries after spinal cord ischemia. We sought to investigate a novel neuroprotective strategy of transplantation of human HGF gene-modified MSCs on ischemic spinal cords.

Methods: Human HGF gene was transferred into MSCs in vitro.

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Objective: Thoracic and thoracoabdominal aortic surgery is sometimes complicated by subacute or delayed paraplegia. Pro-inflammatory cytokine interleukin-1 (IL-1) beta has been implicated in extensive inflammation and progressive neurodegeneration after ischemia. Using a rabbit model, we investigated the neuroprotective effects of IL-1 receptor antagonist (IL-1ra) in a temporal fashion.

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Objective: Reactive free radical species are thought to be involved in postoperative neurologic dysfunction after antegrade selective cerebral perfusion in brains with old infarction. We assessed the brain protective effect of prophylactically administered edaravone, a free radical scavenger, for antegrade selective cerebral perfusion in brains with or without old infarction in a canine model.

Methods: A canine model of old cerebral infarction was created by injecting cylindric silicone embolus into the middle cerebral artery.

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