Effects of cellulose supplementation on fecal consistency and fecal weight.

We investigated the effects of cellulose supplementation on fecal consistency and fecal weight. About 26 women were classified into two groups-normal defecation and constipation groups. All subjects ate the following meals during the experiment: ordinary meals (first week), experimental meals (second week), and experimental meals mixed with 4 g (third week) and 8 g (fourth week) cellulose.

The prevention of colon carcinogenesis in rats by dietary cellulose is greater than the promotive effect of dietary lard as assessed by repeated endoscopic observation.

We developed a method which we used in the current study to observe the rat colon endoscopically. Our goal was to evaluate the entire course in the development of experimental large bowel tumors through serial observations in the same rat. We compared the effects of dietary lard and cellulose on rat colon tumorigenesis in a 2 x 3 factorial design.

Natural History of Colorectal Adenoma and the Effect of Endoscopic Polypectomy on Occurrence of Subsequent Cancer.

Colorectal cancer is thought to originate in colorectal adenoma and endoscopic polypectomy may prove prophylactic. To clarify the natural history of colorectal adenoma and the potential effects of endoscopic polypectomy, we retrospectively studied cohort patients undergoing full colonoscopies at 14 hospitals in Aomori Prefecture between January 1972 and December 1985. Subjects were divided into 3,574 non-adenoma controls and 1,020 adenoma patients, including 530 treated by polypectomy at initial examination.

New method for the determination of fecal consistency and its optimal value in the general population.

Background: Although fecal consistency is an important factor, there has been only one study measuring this parameter. We developed a new method to measure fecal consistency and studied the relationship between fecal consistency and other fecal factors, including water content and weight.

Methods: The new method is a modification of the method of Exton-Smith and used an even balance.

Inhibitory effect of small amounts of cellulose on colonic carcinogenesis with low-dose carcinogen.

This study set out to evaluate the effects of dietary fiber on cancer development in the large bowel under in vivo experimental conditions as similar as possible to those under which this cancer develops in vivo in humans. Forty-eight Sprague-Dawley rats were divided into three groups that were fed either a nonfiber diet or a 3 g or 10 g/100 g cellulose diet in this experiment, and all groups received doses of a mild carcinogen, 1,2-dimethylhydrazine (5 mg/kg body weight) for 50 weeks. Following endoscopic observation of the large bowel, we found that the induction rates of tumor in the cellulose groups were significantly lower than that in the nonfiber diet group, both endoscopically and histologically.