Publications by authors named "Satoru Ikenoue"

Article Synopsis
  • The study aims to compare the effectiveness of controlled-release dinoprostone (PGE) vaginal inserts against mechanical dilation methods for inducing labor before the due date, as research shows PGE may reduce cesarean sections without increasing risks to newborns.
  • The retrospective analysis involved 206 mothers at 37 to 39 weeks of gestation, evaluating perinatal outcomes and the success rates of vaginal deliveries within 48 hours of starting oxytocin augmentation.
  • Results showed a higher success rate of vaginal delivery in the PGE group (80.4%) compared to the non-PGE group (66.2%), with no emergency cesarean sections in the PGE group, suggesting that PGE may be a beneficial option for elective labor
View Article and Find Full Text PDF
Article Synopsis
  • Birth weight is a key factor in assessing risks for perinatal complications and future health issues in children, signaling the importance of fetal development.
  • Maternal factors like obesity, overnutrition, and blood sugar levels (hyperglycemia) significantly influence fetal growth and body composition, which can lead to higher neonatal fat levels.
  • Understanding how fetal fat mass is determined could guide clinical approaches to improve fetal health and help prevent childhood obesity and metabolic disorders later in life.
View Article and Find Full Text PDF
Article Synopsis
  • - This study focused on identifying risk factors that lead to early insulin therapy (before 24 weeks) in pregnant women diagnosed with gestational diabetes early in their pregnancies (E-GDM).
  • - The research analyzed 530 mothers and found that those requiring early insulin therapy had higher maternal age, pre-pregnancy BMI, and glucose levels compared to those managed with diet alone, while also noting lower Apgar scores in the early insulin group.
  • - Findings suggest that diagnosing E-GDM using multiple abnormal oral glucose tolerance test values, particularly high 1-hour plasma glucose levels, could highlight the need for early insulin therapy; further investigation is encouraged.
View Article and Find Full Text PDF

To evaluate perinatal outcomes and risk factors for large for gestational age (LGA; birth weight over 90 percentile) in gestational diabetes diagnosed before 24 gestational weeks and treated with diet therapy alone until delivery (Diet Early gestational diabetes mellitus (Diet Early GDM)), we assessed the maternal characteristics and perinatal outcomes of patients with early GDM ( = 309) and normal glucose tolerance (NGT; = 309) at Keio University Hospital. The gestational weight gain (GWG) expected at 40 weeks was significantly lower in the Diet Early GDM group than in the NGT group. The Diet Early GDM group exhibited a significantly lower incidence of low birth weight (<2500 g) and higher Apgar score at 5 min than the NGT group.

View Article and Find Full Text PDF
Article Synopsis
  • - The study examines how a mother's pre-pregnancy Body Mass Index (BMI) affects the growth of fetal fractional limb volume, which serves as a measure of fetal fatness during pregnancy.
  • - A group of women with normal singleton pregnancies (455 ultrasound scans) were monitored to assess the growth of fetal limb volume from 20 to 40 weeks, revealing a linear increase in the second trimester followed by an exponential growth in the third trimester.
  • - Results indicate that higher maternal pre-pregnancy BMI is significantly linked to larger fetal limb volumes, particularly noted in the later weeks of pregnancy, suggesting that fractional arm volume could reflect the fetal nutritional status as delivery approaches.
View Article and Find Full Text PDF
Article Synopsis
  • In early 2023, a study demonstrated that vaccinating pregnant women effectively reduces the chances of severe COVID-19 complications and maternal health issues.
  • The INTERCOVID-2022 study, conducted across 40 hospitals in 18 countries, analyzed how COVID-19 during pregnancy affects newborns and the benefits of maternal vaccination during the Omicron variant period.
  • Results showed that newborns from mothers who received a booster vaccine had significantly lower risks of contracting COVID-19 and experiencing preterm birth compared to those from unvaccinated mothers.
View Article and Find Full Text PDF

Late preterm (LP, born between 34 0/7 and 36 6/7 weeks of gestation) infants may experience several adverse outcomes, similar to those experienced by low birthweight (LBW, birthweight <2500 g) infants. However, while LP infants are often born with LBW, the association between LP and LBW remains unknown. This study aimed to investigate LBW rate and independent risk factors for LBW in LP singleton neonates.

View Article and Find Full Text PDF

Objective: The authors aimed to investigate the prevalence of pregnancy and obstetric outcomes in patients who underwent radical trachelectomy (RT) for early-stage cervical cancer in the Kanto area, Japan.

Method: A survey among 113 perinatal centers affiliated with the Kanto Society of Obstetrics and Gynecology was conducted to investigate their experience in managing pregnancies following RT, between 2010 and 2020. The association between preterm delivery (before 34 gestational weeks) and a midtrimester short cervix (<13 mm) was evaluated.

View Article and Find Full Text PDF

Hypoglycemia is one of the most significant problems in neonates born to mothers with gestational diabetes (GDM). This study aimed to identify novel predictors of hypoglycemia in neonates born to mothers with GDM. A total of 443 term singleton infants from mothers diagnosed with GDM and cared for at Keio University Hospital between January 2013 and December 2019 were included in this study.

View Article and Find Full Text PDF

This study aimed to investigate the diagnostic accuracy of the placenta accreta index (PAI) for predicting placenta accreta spectrum (PAS) in women with placenta previa. We analyzed 33 pregnancies with placenta previa at Keio University Hospital. The PAI was assessed in the early third trimester, and PAS was diagnosed histologically or clinically defined as retained placenta after manual removal attempts.

View Article and Find Full Text PDF

Background: In 2021, we showed an increased risk associated with COVID-19 in pregnancy. Since then, the SARS-CoV-2 virus has undergone genetic mutations. We aimed to examine the effects on maternal and perinatal outcomes of COVID-19 during pregnancy, and evaluate vaccine effectiveness, when omicron (B.

View Article and Find Full Text PDF

Background: To investigate perinatal outcomes in pregnancy after high-dose medroxyprogesterone acetate (MPA) therapy for early stage endometrial cancer (EC) and atypical endometrial hyperplasia (AEH) and to determine whether pregnancy after MPA therapy is at a higher risk of placenta accreta.

Methods: Data of 51 pregnancies in 46 women who received MPA therapy for EC or AEH and delivered after 22 weeks of gestation at Keio University Hospital were reviewed. A retrospective matched case-control study was performed to determine the risk of placenta accreta in pregnancy after MPA therapy compared with singleton pregnancies without any history of maternal malignancy treatments.

View Article and Find Full Text PDF

Introduction: Little is known about the association between hypospadias and small fetuses, as well as the pathological implications of fetal growth restriction (FGR). Thus, we aimed to investigate the association between hypospadias and small fetuses using a database of fetal ultrasound and obstetric events.

Methods: A cohort of male singleton infants delivered after 22 weeks of gestation at Keio University Hospital between 2013 and 2019 was retrospectively reviewed.

View Article and Find Full Text PDF

Background: Newborns exhibit substantial variation in fat mass accretion over gestation. These individual differences in newborn adiposity extend into infancy and childhood and relate to subsequent risk of obesity and metabolic dysregulation. Maternal glucose homeostasis in pregnancy has been proposed as an underlying mechanism; however, the timing in gestation when maternal glucose regulation influences the progression of fetal fat deposition remain unclear.

View Article and Find Full Text PDF

According to the 2004 Japanese definition, early-onset (EO) preeclampsia (PE) is defined as PE occurring at <32 weeks of gestation. This was based on the presence of "dual peaks" (30-31 and 34-35 weeks) in the prevalence of severe forms of hypertension. In contrast, the international definition adopted a cutoff of 34 weeks based on the consensus.

View Article and Find Full Text PDF

Ascending inflammation from the vagina is a major cause of preterm birth. Currently, this condition-especially when uncontrolled-has no effective treatment. Human amniotic fluid stem cells (hAFSCs) are mesenchymal stem cells known to exert potent anti-inflammatory effects in animal models of perinatal diseases, such as periventricular leukomalacia, myelomeningocele, and neonatal sepsis.

View Article and Find Full Text PDF

Mesenchymal stem cells (MSCs) affect immune cells and exert anti-inflammatory effects. Human amniotic fluid stem cells (hAFSCs), a type of MSCs, have a high therapeutic effect in animal models of inflammation-related diseases. hAFSCs can be easily isolated and cultured from amniotic fluid, which is considered a medical waste.

View Article and Find Full Text PDF

Background: The effect of COVID-19 in pregnancy on maternal outcomes and its association with preeclampsia and gestational diabetes mellitus have been reported; however, a detailed understanding of the effects of maternal positivity, delivery mode, and perinatal practices on fetal and neonatal outcomes is urgently needed.

Objective: To evaluate the impact of COVID-19 on fetal and neonatal outcomes and the role of mode of delivery, breastfeeding, and early neonatal care practices on the risk of mother-to-child transmission.

Study Design: In this cohort study that took place from March 2020 to March 2021, involving 43 institutions in 18 countries, 2 unmatched, consecutive, unexposed women were concomitantly enrolled immediately after each infected woman was identified, at any stage of pregnancy or delivery, and at the same level of care to minimize bias.

View Article and Find Full Text PDF

Background: Progress in reducing the global low birthweight (LBW) has been insufficient. Although the focus has been on preventing preterm birth, evidence regarding LBW in term births is limited. Despite its low preterm birth prevalence, Japan has a higher LBW proportion than other developed countries.

View Article and Find Full Text PDF

Objective: Pregnancy after conization is associated with a high risk of preterm delivery. However, because risk factors for preterm delivery after conization remain unknown, we conducted a multicenter observational study to investigate risk factors associated with preterm delivery.

Methods: We selected patients who had previously undergone conization and reviewed medical records from 18 hospitals in cooperation with Keio University School of Medicine between January 2013 and December 2019.

View Article and Find Full Text PDF

Introduction: Genome-wide methylation analyses of gestational diabetes mellitus (GDM) diagnosed after 24 gestational weeks (late GDM (L-GDM)) using cord blood have been reported. However, epigenetic changes in neonates born to mothers with GDM diagnosed before 24 gestational weeks (early GDM (E-GDM)) have not been reported. We investigated DNA methylation in neonates born to mothers with E-GDM using cord blood samples.

View Article and Find Full Text PDF

Background: Among nonpregnant individuals, diabetes mellitus and high body mass index increase the risk of COVID-19 and its severity.

Objective: This study aimed to determine whether diabetes mellitus and high body mass index are risk factors for COVID-19 in pregnancy and whether gestational diabetes mellitus is associated with COVID-19 diagnosis.

Study Design: INTERCOVID was a multinational study conducted between March 2020 and February 2021 in 43 institutions from 18 countries, enrolling 2184 pregnant women aged ≥18 years; a total of 2071 women were included in the analyses.

View Article and Find Full Text PDF

Massive postpartum hemorrhage (PPH) is the most common cause of maternal death worldwide. A massive transfusion protocol (MTP) may be used to provide significant benefits in the management of PPH; however, only a limited number of hospitals use MTP protocol to manage massive obstetric hemorrhages, especially in Japan. This study aimed to assess the clinical outcomes in patients in whom MTP was activated in our hospital.

View Article and Find Full Text PDF