Publications by authors named "Satomi Kamio"

Article Synopsis
  • Continued use of the antiretroviral drug TDF can lead to kidney issues in HIV patients, while TAF, a newer option, reduces kidney damage but can cause weight gain and lipid metabolism problems.
  • A study analyzed the effects of switching from TDF to TAF among 60 Japanese HIV-1-positive individuals, focusing on kidney function and weight over 288 weeks.
  • Results showed that switching to TAF slowed kidney function decline and reduced protein levels associated with kidney damage, although patients experienced weight gain and lipid changes in the short term.
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Background: Tenofovir disoproxil fumarate (TDF) has a strong antiviral effect, but TDF is known to cause renal dysfunction. Therefore, we are investigating preventing renal dysfunction by replacing TDF with tenofovir alafenamide fumarate (TAF), which is known to be relatively safe to the kidneys. However, the changes in renal function under long-term use of TAF are not known.

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What Is Known And Objective: Augmented renal clearance (ARC; hyperfiltration with over 130 mL/min/1.73 m of creatinine clearance (CL )) commonly occurs in critically ill patients. Recent reports indicate that ARC also occurs in haematologic malignancies.

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This study investigated the effect of bergamot essential oil (BEO) or linalool, a major volatile component of BEO, on the nociceptive response to formalin. Plantar subcutaneous injection of BEO or linalool into the ipsilateral hindpaw reduced both the first and late phases of the formalin-induced licking and biting responses in mice. Plantar subcutaneous injection of BEO or linalool into the contralateral hindpaw did not yield an antinociceptive effect, suggesting that the antinociceptive effect of BEO or linalool in the formalin test occurred peripherally.

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