Publications by authors named "Satomi Imakiire"
Background: In patients with chronic kidney disease (CKD) on hemodialysis, comorbid pulmonary hypertension (PH) aggravates exercise tolerance and eventually worsens the prognosis. The treatment strategy for pre-capillary PH, including combined pre- and post-capillary PH (Cpc-PH), has not been established.
Objectives: This study aimed to evaluate the impact of pulmonary vasodilators on exercise tolerance and pulmonary hemodynamics in patients with CKD on hemodialysis.
Background Recent studies have demonstrated that uric acid (UA) enhances arginase activity, resulting in decreased NO in endothelial cells. However, the role of lung UA in pulmonary arterial hypertension (PAH) remains uncertain. We hypothesized that increased lung UA level contributes to the progression of PAH.
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- Recent research indicates that toll-like receptor 9 (TLR9) plays a role in cardiovascular diseases, but its impact on pulmonary hypertension is still unclear; this study hypothesizes TLR9's involvement in pulmonary hypertension development.
- In a rat model, it was found that TLR9 activation boosts the severity of pulmonary hypertension, linked to increased right ventricular pressure and vascular changes, alongside macrophage accumulation following monocrotaline exposure.
- Using TLR9 inhibitors significantly improved these conditions, suggesting that targeting TLR9 could offer a promising new treatment strategy for pulmonary hypertension by disrupting the NF-κB‒IL-6 signaling pathway.