Publications by authors named "Satomi Harano"
The redback spider () is nonindigenous to Japan but has now spread throughout the country. Bites to humans are rare but can be fatal. We prepared freeze-dried redback spider antivenom for therapeutic use against bites in Japan by immunization of horse plasma.
View Article and Find Full Text PDFIntravenous immunoglobulin (IVIg) has been shown to be effective for a variety of autoimmune diseases. Despite its widespread use and therapeutic success, the precise mechanisms for the anti-inflammatory therapeutic effects of IVIg are not well understood. In particular, few reports have examined the mechanism of IVIg on regulatory T cells (Treg: CD4(+)CD25(+)FoxP3(+) T cells).
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- MC710 is a mixture of plasma-derived activated factor VII (FVIIa) and factor X (FX), designed to manage bleeding in hemophilia patients with inhibitors.
- Pharmacokinetic studies on male rats showed that after a single dose, FVIIa and FX had half-lives of approximately 0.7-6.3 hours and 3.0-4.1 hours, respectively, with significant radioactivity in the plasma.
- About 80% of the administered radioactivity was excreted through urine and feces within 168 hours, while the tissue distribution indicated accumulation of FVIIa and FX in bone and bone marrow.