Periradicular tissue fluid-derived biomarkers for apical periodontitis: An in vitro methodological and in vivo cross-sectional study.

Background: Periradicular tissue fluid (PTF) offers a source of diagnostic, prognostic and predictive biomarkers for endodontic disease.

Aims: (1) To optimize basic parameters for PTF paper point sampling in vitro for subsequent in vivo application. (2) To compare proteomes of PTF from teeth with normal apical tissues (NAT) and asymptomatic apical periodontitis (AAP) using high-throughput panels.

Exploiting Dentine Matrix Proteins in Cell-Free Approaches for Periradicular Tissue Engineering.

The recent discovery of mesenchymal stem cells within periapical lesions (PL-MSC) has presented novel opportunities for managing periradicular diseases in adult teeth by way of enhancing tissue regeneration. This discovery coincides with the current paradigm shift toward biologically driven treatment strategies in endodontics, which have typically been reserved for non-vital immature permanent teeth. One such approach that shows promise is utilizing local endogenous non-collagenous dentine extracellular matrix components (dECM) to recruit and upregulate the intrinsic regenerative capacity of PL-MSCs .

Indocyanine green-mediated antimicrobial photodynamic therapy as an adjunct to periodontal therapy: a systematic review and meta-analysis.

Objectives: The aim of this systematic review and meta-analysis was to evaluate the efficacy of indocyanine green-mediated photodynamic therapy (ICG-PDT) as an adjunct to non-surgical periodontal therapy (NSPT), in the management of chronic periodontitis.

Materials And Methods: Four electronic databases (PubMed, Cochrane Central Register of Controlled Trials, Embase via OVID, Web of Science) were searched for randomised controlled trials comparing NSPT with ICG-PDT to NSPT without laser therapy. Primary outcome measures were changes in probing pocket depth (PPD) and clinical attachment level (CAL).

Current trends in endodontic irrigation amongst general dental practitioners and dental schools within the United Kingdom and Ireland: a cross-sectional survey.

Aims To investigate current trends in endodontic irrigation amongst general dental practitioners (GDPs) and dental schools within UK and Ireland. Secondly, to evaluate if significant differences exist between the irrigant practices of National Health Service (NHS) and private GDPs.Methodology In 2019, an online questionnaire was distributed to the 18 dental schools within the UK and Ireland and 8,568 GDPs.

The role of the GP in managing suspected transient ischaemic attack: a qualitative study.

Background: National guidelines recommend patients with suspected transient ischaemic attack (TIA) should be seen by a specialist within 24 h. However, people with suspected TIA often present to non-specialised services, particularly primary care. Therefore, general practitioners (GPs) have a crucial role in recognition and urgent referral of people with suspected TIA.

Postoperative Complications Following LeFort 1 Maxillary Advancement Surgery in Cleft Palate Patients: A 5-Year Retrospective Study.

Objective: To investigate the postoperative complication rates of LeFort 1 maxillary advancement surgery in cleft patients when performed by a single surgeon over a 5-year period.

Design: A retrospective case note review of 79 cleft palate patients.

Setting: All surgery was performed by a single oral and maxillofacial surgeon in a tertiary care center.

Striking back against racist violence in the East End of London, 1968-1970.

This article tells the hitherto untold story of how different Pakistani organisations mobilised in response to racist violence and harassment in the east London Borough of Tower Hamlets (1968-1970). In telling this story, the authors analyse the problematic nature of official and public understandings of, and responses to, racist violence, and how it distorted the lives of racialised minorities. Drawing on original archival research carried out in 2014, this piece identifies the emergence of two distinct political repertoires from within the Pakistani community: the integrationist approach and the autonomous approach.

Effective Pain Management Strategies in Endodontic Therapy.

Pain management is the key to providing successful root canal therapy. All patients hope for a painless procedure and look forward to being free of their symptoms when treatment is complete. However, managing pain throughout endodontic therapy can be challenging and improving awareness of various analgesic techniques can make a significant difference to both patient and practitioner.

Different systolic blood pressure targets for people with history of stroke or transient ischaemic attack: PAST-BP (Prevention After Stroke--Blood Pressure) randomised controlled trial.

Objective: To assess whether using intensive blood pressure targets leads to lower blood pressure in a community population of people with prevalent cerebrovascular disease.

Design: Open label randomised controlled trial.

Setting: 99 general practices in England, with participants recruited in 2009-11.

Patients' views about taking a polypill to manage cardiovascular risk: a qualitative study in primary care.

Background: A 'polypill' containing a combination of antihypertensives and statins could prevent up to 80% of cardiovascular disease (CVD) events.

Aim: To investigate patients' opinions about the use of a polypill for CVD prevention.

Design And Setting: Qualitative study of 17 patients from seven primary care practices in Birmingham, UK.

"And now for the good news..." the impact of negative and positive messages in self-management education for people with Type 2 diabetes: A qualitative study in an ethnically diverse population.

Objectives: To explore the impact of Diabetes Education and Self Management for Ongoing and Newly Diagnosed (DESMOND) Foundation education, particularly from interviewees' narratives regarding recall of good and bad news messages and behaviour changes.

Methods: In-depth, semi-structured interviews were conducted with a purposive sample (n=19) of people who had attended education sessions as part of a randomised controlled trial in two UK sites with ethnically diverse populations. Data collection and analysis were informed by the constant comparative approach and facilitated through charting.

Would primary healthcare professionals prescribe a polypill to manage cardiovascular risk? A qualitative interview study.

Objectives: A 'polypill' containing both blood pressure-lowering and cholesterol-lowering drugs could prevent up to 80% of cardiovascular disease events. Since little is known about the attitudes of primary healthcare professionals to use of such a pill for cardiovascular disease prevention, this study aimed to investigate opinions.

Design: Semistructured interviews were conducted with participants.

Varying uses of the ABCD2 scoring system in primary and secondary care: a qualitative study.

Objectives: To explore the usage of the ABCD2 risk stratification score by general practitioners (GPs) and hospital staff during the referral of patients with suspected transient ischaemic attack (TIA) or minor stroke.

Design: Qualitative study using semistructured interviews.

Setting: Nine general practices and two hospital sites in England (Birmingham and Cambridge).

Patients' experiences of self-monitoring blood pressure and self-titration of medication: the TASMINH2 trial qualitative study.

Background: Self-management of hypertension, comprising self-monitoring of blood pressure with self-titration of medication, improves blood pressure control, but little is known regarding the views of patients undertaking it.

Aim: To explore patients' views of self-monitoring blood pressure and self-titration of antihypertensive medication.

Design And Setting: Qualitative study embedded within the randomised controlled trial TASMINH2 (Telemonitoirng and Self Management in the Control of Hypertension) trial of patient self-management of hypertension from 24 general practices in the West Midlands.

Protocol for Past BP: a randomised controlled trial of different blood pressure targets for people with a history of stroke of transient ischaemic attack (TIA) in primary care.

Background: Blood pressure (BP) lowering in people who have had a stroke or transient ischaemic attack (TIA) leads to reduced risk of further stroke. However, it is not clear what the target BP should be, since intensification of therapy may lead to additional adverse effects. PAST BP will determine whether more intensive BP targets can be achieved in a primary care setting, and whether more intensive therapy is associated with adverse effects on quality of life.

Racism and the sociological imagination.

Our chief purpose in this article is to argue for a restoration of a strong notion of agency to sociological accounts of social relations, and particularly those concerned with group formation and conflict. We contend that much contemporary sociological writing on this topic continues to rely on the concepts of race and ethnicity as primary explanatory or descriptive devices. This has two important consequences: on the one hand it reproduces the powerful theoretical obfuscation associated with these concepts, whilst on the other it prompts the notion that human agency has only an illusory role as an intentional agent.

Migrant labour, racism and the British National Health Service.

This study explores the dynamics of racism, specifically its generation and reproduction as an ideology, and its role in affecting the reception and occupational location of migrant medical labour in Britain. It is argued that the treatment of 'overseas doctors' in Britain draws on a complex interplay between racism and nationalism underpinned by the historical construction of 'welfarism' as a moral legitimator of 'Britishness'. Through an exploration of internal and external immigration controls introduced with the aim of regulating migrant labour, we demonstrate how British social policy and elite discourses of 'race' combine to construct moral prescriptions of threat such that migrants and British-born 'non-whites' entering the British medical profession are forced to negotiate 'saviour/pariah' ascriptions indicative of discriminatory but contradictory processes specific to the operation of the British National Health Service as a normative institution.