Study of Caregiver Burden in Continuous Ambulatory Peritoneal Dialysis.

Background: Increased caregiver burden undermines caregivers' mental and physical health and is an under recognized but critical aspect for the success of continuous ambulatory peritoneal dialysis (CAPD). This study was undertaken to quantify and identify the factors determining CAPD caregiver burden.

Materials And Methods: A cross-sectional study was conducted among 51 caregivers of CAPD patients visiting the centers from July to August 2023.

Dual carbon isotope-based brown carbon aerosol characteristics at a high-altitude site in the northeastern Himalayas: Role of biomass burning.

PM samples (n = 34) were collected from January to April 2017 over Shillong (25.7°N, 91.9°E; 1064 m amsl), a high-altitude site situated in the northeastern Himalaya.

Wintertime oxidative potential of PM over a big urban city in the central Indo-Gangetic Plain.

Indo-Gangetic Plain (IGP) experiences a heavy load of particulate pollution impacting the 9 % of the global population living in this region. The present study examines the dithiothreitol (DTT) assay-based oxidative potential (OP) of PM and the major sources responsible for the observed OP over the central IGP (Kanpur) during winter. The volume normalized OP (OP) of PM varied from 2.

Factors associated with adolescent pregnancy in Maharashtra, India: a mixed-methods study.

Reducing the adolescent birth rate is paramount in achieving the health-related Sustainable Development Goals, given that pregnancy and childbirth are the leading cause of mortality among young women aged 15-19. This study aimed to explore predictors of adolescent pregnancy among girls aged 13-18 years in Maharashtra, India, during the COVID-19 pandemic. Using a mixed-methods approach, primary data were gathered from two regions in Maharashtra between February and April 2022.

Exosomes from metastatic colon cancer cells drive the proliferation and migration of primary colon cancer through increased expression of cancer stem cell markers CD133 and DCLK1.

The exchange of biological material between the neighbouring cells is essential for homeostasis. In pathological conditions, such as cancer, the major challenge in cancer treatment is the abnormal expression of crucial proteins and miRNA exchanged between the cancer cells through extracellular vesicles called exosomes. Clinically, it has been noticed that the primary tumour and the distal metastases are interconnected and co-dependent.

Comparative Evaluation of Fibrin Network Formation after Root Conditioning using Erbium, Chromium-Doped Yttrium Scandium Gallium and Garnet Laser, Ethylene-Diamine-Tetra-Acetic Acid, and Tetracycline on Dentin: A Scanning Electron Microscopic Study.

Context: Regeneration of periodontal tissues depend on the adhesion and development of fibrin clots to the root surface. Demineralization of the root surface ensures removal of smear layer uncovering dentin tubules and collagen matrix. Root conditioning agents were introduced to remove the smear layer and enhance the adhesion of blood components.

Characterization of paddy-residue burning derived carbonaceous aerosols using dual carbon isotopes.

A large scale paddy-residue burning (PRB) happens every year in the northwest Indo-Gangetic Plain (IGP) during the post-monsoon season, and winds transport pollutants from the source region up to the northern Indian Ocean affecting air quality of the IGP and marine region. In this study, day-night pairs of fine aerosol samples (n = 69) were collected during October-November over Patiala (30.2°N, 76.

Learning effective embedding for automated COVID-19 prediction from chest X-ray images.

The pandemic that the SARS-CoV-2 originated in 2019 is continuing to cause serious havoc on the global population's health, economy, and livelihood. A critical way to suppress and restrain this pandemic is the early detection of COVID-19, which will help to control the virus. Chest X-rays are one of the more straightforward ways to detect the COVID-19 virus compared to the standard methods like CT scans and RT-PCR diagnosis, which are very complex, expensive, and take much time.

Atmospheric chemistry and cancer risk assessment of Polycyclic Aromatic Hydrocarbons (PAHs) and Nitro-PAHs over a semi-arid site in the Indo-Gangetic plain.

Polycyclic Aromatic Hydrocarbons (PAHs) and Nitro-PAHs were collected over a year at a traffic dominated site in Agra, to determine the dominant partitioning mechanism. During the entire sampling period, total PAHs and Nitro-PAHs were 3465 ± 3802 and 26.1 ± 25.

One-year clinical evaluation of bulk-fill composite resin restorations plasticized by preheating and ultrasonics: A randomized clinical trial.

Introduction: Bulk-fill composite restorations displayed substantial annual failure related to imperfect marginal adaptation. Although preheated composites improved, marginal adaptation demonstrated early loss of plasticity. A new technique of ultrasonics plasticization was used for fabricating restorations.

Comparative evaluation of the effect of adhesive restorative composite resins on the reinforcement of peri-cervical dentin: An study.

Background: Peri-cervical dentin (PCD) and its reinforcement play a crucial role in the fracture resistance of root canal-treated teeth.

Aims: The aim of this study was to compare the fracture resistance of dual-cure, nano-hybrid, and short-fiber reinforced composite resins restored PCD with conventional hybrid composite (CHC) resin restored endodontically treated mandibular premolars.

Settings And Design: Academic, study.

ACE2, Circumventricular Organs and the Hypothalamus, and COVID-19.

The SARS-CoV-2 virus gains entry to cells by binding to angiotensin-converting enzyme 2 (ACE2). Since circumventricular organs and parts of the hypothalamus lack a blood-brain barrier, and immunohistochemical studies demonstrate that ACE2 is highly expressed in circumventricular organs which are intimately connected to the hypothalamus, and the hypothalamus itself, these might be easy entry points for SARS-CoV-2 into the brain via the circulation. High ACE2 protein expression is found in the subfornical organ, area postrema, and the paraventricular nucleus of the hypothalamus (PVH).

Diurnal variability in the spectral characteristics and sources of water-soluble brown carbon aerosols over Delhi.

It is well established that light-absorbing organic aerosols (commonly known as brown carbon, BrC) impact climate. However, uncertainties remain as their contributions to absorption at different wavelengths are often ignored in climate models. Further, BrC exhibits differences in absorption at different wavelengths due to the variable composition including varying sources and meteorological conditions.

Real-time characterization and source apportionment of fine particulate matter in the Delhi megacity area during late winter.

National Capital Region (NCR) encompassing New Delhi is one of the most polluted urban metropolitan areas in the world. Real-time chemical characterization of fine particulate matter (PM and PM) was carried out using three aerosol mass spectrometers, two aethalometers, and one single particle soot photometer (SP2) at two sites in Delhi (urban) and one site located ~40 km downwind of Delhi, during January-March 2018. The campaign mean PM (NR-PM + BC) concentrations at the two urban sites were 153.

Parathyroid allotransplantation to treat post-thyroidectomy hypoparathyroidism: A review of case studies.

Objective: Symptomatic long-term hypoparathyroidism following thyroid surgery requires an alternative and permanent therapy that would effectively restore parathyroid function and eliminate the need for substitution drug therapy. The aim of this study was to systematically review the literature on the efficacy and safety of parathyroid allotransplantation to treat post-operative hypoparathyroidism.

Methods: MEDLINE, Embase, BIOSIS and the Cochrane Library were searched for published articles (from inception of each database to September 30, 2018).

Change in characteristics of water-soluble and water-insoluble brown carbon aerosols during a large-scale biomass burning.

Light-absorbing organic aerosol (brown carbon (BrC)) can significantly affect Earth's radiation budget and hydrological cycle. Biomass burning (BB) is among the major sources of atmospheric BrC. In this study, day/night pair (10-h integrated) of ambient PM were sampled every day before (defined as T1, n = 21), during (T2, n = 36), and after (T3, n = 8) a large-scale paddy-residue burning during October-November over Patiala (30.

Chemical and isotopic characteristics of PM over the Bay of Bengal: Effects of continental outflow on a marine environment.

Pollutants transport from South and Southeast Asia can profoundly affect the marine atmospheric boundary layer (MABL) over the Bay of Bengal (BoB). This study presents chemical and stable isotopic composition of PM collected at Port Blair Island (11.6°N, 92.

Hydrogen-Bonding Interactions in Hybrid Aqueous/Nonaqueous Electrolytes Enable Low-Cost and Long-Lifespan Sodium-Ion Storage.

Although "water-in-salt" electrolytes have opened a new pathway to expand the electrochemical stability window of aqueous electrolytes, the electrode instability and irreversible proton co-insertion caused by aqueous media still hinder the practical application, even when using exotic fluorinated salts. In this study, an accessible hybrid electrolyte class based on common sodium salts is proposed, and crucially an ethanol-rich media is introduced to achieve highly stable Na-ion electrochemistry. Here, ethanol exerts a strong hydrogen-bonding effect on water, simultaneously expanding the electrochemical stability window of the hybridized electrolyte to 2.

Mucoadhesive Particles: A Novel, Prolonged-Release Nanocarrier of Sitagliptin for the Treatment of Diabetics.

Sitagliptin (MK-0431) is a widely and commonly used oral hypoglycemic drug in the treatment of type 2 diabetes mellitus; patients typically take higher doses of this drug (50 mg, twice daily). One drawback is that only 38% of the drug is bound reversibly to plasma proteins and 79% is excreted in urine without being metabolized. To overcome this issue, there is a need for a better drug-delivery method to improve its efficacy in patients.

On the Use of Brown Carbon Spectra as a Tool to Understand Their Broader Composition and Characteristics: A Case Study from Crop-residue Burning Samples.

This study proposes a novel approach to the use of brown carbon (BrC) absorption spectra as a tool to understand their broader composition and characteristics. The ratios of absorption coefficient ( ) spectra over a wavelength range (310-600 nm) for water-soluble and methanol-soluble BrC were used to quantify the relative contribution of water-soluble and water-insoluble chromophores to total BrC. The same ratios for the samples collected during the day versus night were used to assess the diurnal variability in BrC composition and concentrations.