Publications by authors named "Satiro Nakamura de Oliveira"
Article Synopsis
- Allogeneic hematopoietic cell transplantation (HCT) in pediatric patients can lead to serious complications, requiring intensive care for a notable percentage of patients post-transplant.
- A study analyzing data from multiple centers found that about 15.3% of patients needed ICU care within 5 years, with factors like patient demographics and pre-existing conditions influencing this need.
- Although survival to discharge from the ICU is high (85.7%), many patients face ongoing health issues, resulting in a significant drop in long-term survival rates, especially among those with malignancies and poor organ function.
Article Synopsis
- Allogeneic hematopoietic cell transplantation (HCT) can lead to complications requiring intensive care, but the risk factors for these complications are not well understood due to differences among treatment centers.
- The study analyzed data from 6,995 pediatric HCT patients and found that 1,067 of them needed intensive care, with higher admission rates linked to factors like younger age, lower income, and certain pre-existing health conditions.
- Among those who were admitted to intensive care, the survival rate to discharge was 85.7%, but many experienced readmissions, and overall long-term survival rates were significantly worse for patients with certain risk factors, particularly those with malignant diseases or existing organ dysfunction.*
Management of patients with central nervous system tumors relies largely on magnetic resonance imaging scans to document disease progression or recurrence. The finding of new lesions always presents the challenge of differentiating between post-surgical changes, radiation necrosis, gliosis, and tumor, submitting these patients to more aggressive therapy and more toxicity. We reviewed the medical records of three patients with primary central nervous system tumors treated at the Children's Hospital Los Angeles who had new false-positive magnetic resonance imaging findings suggestive of tumor recurrence.
View Article and Find Full Text PDFChimeric antigen receptors (CARs) against CD19 have been shown to direct T-cells to specifically target B-lineage malignant cells in animal models and clinical trials, with efficient tumor cell lysis. However, in some cases, there has been insufficient persistence of effector cells, limiting clinical efficacy. We propose gene transfer to hematopoietic stem/progenitor cells (HSPC) as a novel approach to deliver the CD19-specific CAR, with potential for ensuring persistent production of effector cells of multiple lineages targeting B-lineage malignant cells.
View Article and Find Full Text PDF[Radiotherapy for pancreatic cancer].
Rev Assoc Med Bras (1992)
December 2002
Background: The pancreatic adenocarcinoma is an aggressive disease for which cure is only possible in less than 20% of the best cases. Adjuvant radiotherapy and chemotherapy so far have improved symptoms with little, but significant, increase in survival rates.
Methods: Retrospective assessment of 40 patients admitted at Department of Radiation Oncology of the Hospital Israelita Albert Einstein between April 1993 and August 1999 was done.