Whole-Genome Sequencing to Identify Missed Rifampicin and Isoniazid Resistance Among Tuberculosis Isolates-Chennai, India, 2013-2016.

India has a high burden of drug-resistant tuberculosis (DR TB) and many cases go undetected by current drug susceptibility tests (DSTs). This study was conducted to identify rifampicin (RIF) and isoniazid (INH) resistance associated genetic mutations undetected by current clinical diagnostics amongst persons with DR TB in Chennai, India. Retrospectively stored 166 DR TB isolates during 2013-2016 were retrieved and cultured in Löwenstein-Jensen medium.

Why African Americans say "No": A Study of Pharmacogenomic Research Participation.

Objective: To identify reasons for nonparticipation by African Americans in cardiovascular pharmacogenomic research.

Design: Prospective, open-ended, qualitative survey.

Setting: Research staff approached patients eligible for the Discovery Project of The African American Cardiovascular pharmacogenomics CONsorTium in the inpatient or outpatient setting at four different institutions during September and October 2018.

Long-term health-related quality of life in living liver donors: A south Asian experience.

Aim: The aim of this study was to evaluate long-term health-related quality of life (HRQOL), changes in lifestyle, and complications in living liver donors at a single transplant center from southern India.

Methods: A total of 64 consecutive living liver donors from 2008 to 2011 were evaluated; 46 of 64 donors completed the short form 36 (SF-36) via telephonic interviews or clinic consultations. Mean follow-up was 48 months (range: 37-84 months).

Better innovate than compromise: a novel hepatic outflow reconstruction technique in pediatric living donor liver transplantation.

Pediatric LDLT using donors with unfavorable vascular anatomy is challenging in terms of donor safety, and complexity of reconstruction in the recipient. We describe an innovative technique of hepatic venous outflow reconstruction involving the recipient RHV, in the presence of a rudimentary RHV in the donor. The postoperative course of the donor and recipient was uneventful with satisfactory venous outflow in both.

Growth of ZnS nanostructures in high vacuum by thermal evaporation.

ZnS nanostructures were grown on Si substrates in high vacuum by modified thermal evaporation technique. Morphology, chemical composition and structural properties of grown ZnS nanostructures were studied using scanning electron microscope (SEM), X-ray diffractometer and transmission electron microscope (TEM). SEM studies showed that morphology of the grown structures varies with incident flux and source temperature.

The effect of gold and iron-oxide nanoparticles on biofilm-forming pathogens.

Microbial biofilms on biomaterial implants or devices are hard to eliminate by antibiotics due to their protection by exopolymeric substances that embed the organisms in a matrix, impenetrable for most antibiotics and immune-cells. Application of metals in their nanoparticulated form is currently considered to resolve bacterial infections. Gold and iron-oxide nanoparticles are widely used in different medical applications, but their utilisation to eradicate biofilms on biomaterials implants is novel.

Profile and outcome of patients with liver cirrhosis requiring mechanical ventilation.

Objective: Few studies have addressed the outcome of patients with cirrhosis requiring mechanical ventilation (MV). We aimed to investigate the short-term outcome of such patients.

Methods: Retrospective review of data of 73 consecutive patients with cirrhosis requiring MV over a 2-year period (2006-2008).

Ultrasound-guided femoral dialysis access placement: a single-center randomized trial.

Background And Objectives: Insertion of dialysis catheters (DCs) is a prerequisite for successful initiation of hemodialysis. We attempted to determine if ultrasonography-guided (USG) insertion was superior and safer than the anatomical landmark-guided technique (ALT) for the femoral vein (FV).

Design, Setting, Participants, & Measurements: This was a randomized prospective study on 110 patients requiring FV DCs in a tertiary care hospital.

Outcome of patients with liver cirrhosis admitted to a specialty liver intensive care unit in India.

Purpose: The study aimed to describe the clinical outcome of patients with liver cirrhosis admitted to intensive care unit (ICU) and to compare the performance of Acute Physiology and Chronic Health Evaluation (APACHE) II and Sequential Organ Failure Assessment (SOFA) in predicting mortality.

Methods: In this prospective study of patients with cirrhosis admitted to the ICU, demographic data, APACHE II score, SOFA score, presence of acute renal failure (ARF), need for organ support, and mortality were collected.

Results: The observed mortality in ICU and at 30 days among 104 patients was 42.

Ethyl 4'-ethenyl-2'-oxo-4-phenyl-2-(3,4,5-trimethoxy-phen-yl)spiro-[pyrrolidine-3,3'-indoline]-5-carboxyl-ate monohydrate.

In the title compound, C(31)H(32)N(2)O(6)·H(2)O, the pyrrolidine ring adopts an envelope conformation. The ethyl C atoms of the ethoxy-cabonyl group are disordered over two positions with occupancies of ca 0.80 and 0.