Publications by authors named "Sathya Narayanan Govindarajulu"
Article Synopsis
- * Recent research points to a neuroendocrine origin for PCOS, suggesting that hormonal and brain circuit interactions may play a key role in the disorder's symptoms, such as polycystic ovaries and insulin resistance.
- * The review highlights various neuropeptides (like Kisspeptin and Ghrelin) and their potential roles in PCOS, aiming to establish new drug targets that could improve treatment options for the condition.
Background: Bromelain is a complex mixture of protease enzyme extract from the fruit or stem of the pineapple plant and it has a history of folk medicine use. It is known to have a wide range of biological actions and it is most commonly used as an anti-inflammatory agent, though scientists have also discovered its potential as an anticancer and antimicrobial agent, it has been reported to have positive effects on the respiratory, digestive, circulatory systems and potentially on the immune system.
Objective: This study was designed to investigate the antidepressant potential of Bromelain in the chronic unpredictable stress (CUS) model of depression.
Gut peptides are small peptides secreted by gut endocrine cells that can modulate the roles and functions of different organs through signaling. Gut peptides can also majorly impact the body's energy homeostasis by regulating appetite and energy metabolism. The gut-brain axis (GBA) is bidirectional communication between the central nervous system (CNS) and the peripheral enteric nervous system.
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