Clinical Spectrum of Monogenic Infantile-Onset Inflammatory Bowel Disease.

Very-early-onset IBD and infantile-onset IBD is extremely rare in children. There is paucity of data with regards to clinical profile and outcome of children with infantile-onset IBD from India. The clinicolaboratory profile, molecular genetic testing and treatment details of 8 children diagnosed with monogenic infantile-onset IBD during 2015-2020 is described here.

Partial internal biliary diversion: a solution for intractable pruritus in progressive familial intrahepatic cholestasis type 1.

Biliary diversion offers a potential option for intractable pruritus in children with chronic cholestatic disorders. Progressive familial intrahepatic cholestasis (PFIC) is an inherited disorder of impaired bile acid transport and excretion, which presents with jaundice and pruritus in the first few months of life and progresses to cirrhosis by infancy or adolescence. We report a child with PFIC type 1 who underwent internal biliary diversion for intractable pruritus and was relieved of his symptoms.

Therapeutic misadventure with paracetamol in children.

Paracetamol (acetaminophen), though considered a safe, "over the counter" analgesic and antipyretic, can cause liver injury with overdose. Therapeutic misadventure is a unique problem where the existing nomogram used for acute poisoning is not applicable. In this context, early initiation of N-acetylcysteine even before a biochemical evidence of liver injury may be beneficial.

Chronic abdominal pain in children.

Chronic abdominal pain (CAP) continues to be a diagnostic and therapeutic challenge. It affects about 10% of school-going children and adolescents. Few Indian studies have reported an organic cause in 30%-40% of children with recurrent abdominal pain.

Profile of typhoid fever in children from a tertiary care hospital in Chennai-South India.

Aim: To study the clinical profile and outcome of hospitalized children with typhoid fever.

Materials And Methods: A retrospective study was conducted in a private tertiary care children's hospital over a 3 year period.

Results: A total of 316 children (7 in every 1000 admissions) were diagnosed to have typhoid fever during this period.

Nocturnal cough and esophagogastric polyp: causal or casual association?

A 6-year-old boy presented with nocturnal cough of 8 months duration. Upper gastrointestinal endoscopy (UGIE) showed an esophagogastric polyp and esophagitis. The 24 hours ambulatory pH recording revealed moderate gastro esophageal reflux (GER) and esophageal manometry demonstrated hypotensive lower esophageal sphincter (LES).