Publications by authors named "Sathish Subbaiah"
Stroke is the leading cause of disability in much of the world, with few treatment options available. Following unilateral stroke in rats, inosine, a naturally occurring purine nucleoside, stimulates the growth of projections from the undamaged hemisphere into denervated areas of the spinal cord and improves skilled use of the impaired forelimb. Inosine augments neurons' intrinsic growth potential by activating Mst3b, a component of the signal transduction pathway through which trophic factors regulate axon outgrowth.
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- Recovery from brain injuries like stroke is limited by the ability of surviving neurons to form new connections, but inosine can help enhance this process.
- Inosine stimulates the growth of axons and improves the recovery of functions in the brain by promoting changes in gene expression in unaffected neurons.
- In experiments, inosine treatment resulted in a notable increase in axon connections in the spinal cord, which correlated with improved motor skills in animals using their affected limbs.