Inflammation and Related Signaling Pathways in Acute Myeloid Leukemia.

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy, and inflammatory signaling is involved in its pathogenesis. Cytokines exert a robust effect on the progression of AML and affect survival outcomes. The dysregulation in the cytokine network may foster a pro-tumorigenic microenvironment, increasing leukemic cell proliferation, decreasing survival and driving drug resistance.

Microstructure and dry sliding wear evaluation of functionally graded coating deposited via atmospheric plasma spray.

Surfaces are commonly enhanced with wear-resistant coatings to improve their resistance to abrasion, erosion, and other forms of wear. These coatings play a crucial role in extending the lifespan and improving the performance of materials and components exposed to challenging conditions. The objective of the current study is to deposit thermally sprayed 3-layer TiC-12Co-10ZrO/NiCoCrAlMo functionally graded coatings on SS410 substrates using atmospheric plasma spray.

Microplastics contamination in commercial fish meal and feed: a major concern in the cultured organisms.

The growing scale of plastic pollution causes a devastating impact on the aquatic ecosystem. The people largely depend on animal-based food for their protein requirements. In this study, we analysed 10 different fish meal samples and 20 feed samples used in farming to understand the level of microplastic (MPs) contamination and estimate the amount of MPs ingested by farmed fish, shrimp, and chicken through feed.

Tailoring of High-Valent Sn-Doped Porous NaV(PO)/C Nanoarchitechtonics: An Ultra High-Rate Cathode for Sodium-Ion Batteries.

NASICON structured NaV(PO) (NVP) has captured enormous attention as a potential cathode for next-generation sodium-ion batteries (SIBs), owing to its sturdy crystal structure and high theoretical capacity. Nonetheless, its poor intrinsic electronic conductivity has led to inferior electrochemical performance in terms of rate capability and long cycling performance. To address this problem, a combined strategy is adopted, such as (1) carbon coating and (2) high valent Sn ion doping in the lattice site of vanadium in the NVP cathode.

In-Situ Nanoarchitectonics of Fe/Co LDH over Cobalt-Enriched N-Doped Carbon Cookies as Facile Oxygen Redox Electrocatalysts for High-Rate Rechargeable Zinc-Air Batteries.

The reality of long-term rechargeable and high-performance zinc-air batteries relies majorly on cost-effective and eminent bifunctional electrocatalysts, which can perform both the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER). Herein, we demonstrate a new approach for the synthesis of in-situ-grown layered double hydroxide of iron and cobalt over a cobalt nanoparticle-enriched nitrogen-doped carbon frame (CoL 2:1) by a simple coprecipitation reaction with facile scale-up and explore its electrocatalytic ORR and OER activity for an electrically rechargeable zinc-air battery. Consequently, the developed composite displays excellent ORR and OER activity with an ORR half-wave potential of 0.

Recent advancements in sustainable synthesis of zinc oxide nanoparticles using various plant extracts for environmental remediation.

The sustainable synthesis of zinc oxide nanoparticles (ZnO-NPs) using plant extracts has gained significant attention in recent years due to its eco-friendly nature and potential applications in numerous fields. This synthetic approach reduces the reliance on non-renewable resources and eliminates the need for hazardous chemicals, minimizing environmental pollution and human health risks. These ZnO-NPs can be used in environmental remediation applications, such as wastewater treatment or soil remediation, effectively removing pollutants and improving overall ecosystem health.

Comparative study on the status of microplastics in different functional areas of Tuticorin, Southeast coast of India.

Microplastics (MPs) and the pollutants associated with them pose a significant risk to the aquatic ecosystems. This study analysed the spatial and seasonal differences in MPs in terms of diversity, inventory and associated heavy metals, and assessed the risk carried by MPs in different functional areas of Tuticorin, southeast coast of India. The mean MPs abundance varies from 5.

Continuous Infusion Versus Bolus Injection of Loop Diuretics for Patients With Congestive Heart Failure: A Meta-Analysis.

Loop diuretics continue to be a crucial component of pharmacological treatment, to eliminate extra fluid and enhance symptom control in acute decompensated heart failure (ADHF). Understanding the loop diuretics' more efficient form of administration would be very beneficial in improving the management of people's ADHF, resulting in a quicker resolution of symptoms and a notable decrease in morbidity. To assess the outcomes of intravenous continuous infusion with bolus injection of loop diuretics for patients with ADHF, this meta-analysis was carried out.

Nanoporous Hollow Carbon Spheres Derived from Fullerene Assembly as Electrode Materials for High-Performance Supercapacitors.

The energy storage performances of supercapacitors are expected to be enhanced by the use of nanostructured hierarchically micro/mesoporous hollow carbon materials based on their ultra-high specific surface areas and rapid diffusion of electrolyte ions through the interconnected channels of their mesoporous structures. In this work, we report the electrochemical supercapacitance properties of hollow carbon spheres prepared by high-temperature carbonization of self-assembled fullerene-ethylenediamine hollow spheres (FE-HS). FE-HS, having an average external diameter of 290 nm, an internal diameter of 65 nm, and a wall thickness of 225 nm, were prepared by using the dynamic liquid-liquid interfacial precipitation (DLLIP) method at ambient conditions of temperature and pressure.

Chloroquine-Induced Psychosis: A Case Report.

The use of antimalarial drugs for prophylaxis is a widespread practice while traveling to underdeveloped nations, particularly those with a high malaria prevalence. Chloroquine is still one of the most commonly recommended antimalarials, either alone or in combination with others, for prophylaxis. However, its increased use over the past few decades has been associated with many adverse effects, including headaches, dizziness, vomiting, and diarrhea, as well as neuropsychiatric symptoms such as psychosis.

Green Chemistry Based Synthesis of Zinc Oxide Nanoparticles Using Plant Derivatives of (Giant Milkweed) and Its Biological Applications against Various Bacterial and Fungal Pathogens.

Nanotechnology is a burning field of scientific interest for researchers in current era. Diverse plant materials are considered as potential tool in green chemistry based technologies for the synthesis of metal nanoparticles (NPs) to cope with the hazardous effects of synthetic chemicals, leading to severe abiotic climate change issues in today's agriculture. This study aimed to determine the synthesis and characterization of metal-based nanoparticles using extracts of the selected and to evaluate the enzyme-inhibition activities and antibacterial and antifungal activity of extracts of metal-based zinc nanoparticles using extracts.

Bupropion-Induced Dystonia: A Case Report.

Bupropion is one of the most commonly prescribed antidepressant medications by physicians all over the world. Because of its favorable sexual profile, it is used as an alternative to serotonin reuptake inhibitors (SSRIs). Its significance in smoking cessation is also well recognized.

Beta-Blocker-Induced Erythrodermic Psoriasis: A Case Report.

Beta-blockers are well-known for their wide range of therapeutic applications, particularly in patients with cardiac diseases. Physicians worldwide are aware of their potential side effects, including hypoglycemia, dizziness, slow heart rate, fatigue, and heart block. We report a case of erythrodermic psoriasis caused by beta-blockers in a 61-year-old woman with no prior history of the skin condition.

Bifunctional g-CN/carbon nanotubes/WO ternary nanohybrids for photocatalytic energy and environmental applications.

Ternary nanohybrids based on mesoporous graphitic carbon nitride (g-CN) were synthesized and presented for developing stable and efficient Hydrogen (H) production system. Based on photocatalytic activity, optimization was performed in three different stages to develop carbon nanotubes (CNTs) and WO loaded g-CN (CWG-3). Initially, the effect of exfoliation was investigated, and a maximum specific surface area of 100.

Biochar for Supercapacitor Application: A Comparative Study.

Biochar is a carbon-rich solid that can be prepared through heat treatment of biomass under an inert atmosphere. In the present work, biochar prepared from different feedstocks, namely, Litchi chinensis (Litchi) seeds, Syzygium cumini (Jamun) seeds, and pine cone, were evaluated for charge storage in the form of supercapacitors. The physicochemical and electrochemical properties of the biochar were highly dependent on the preparation temperature and the choice of feedstock.

Enantioselective Imine Reduction of Dihydro-β-carbolines by Fe-Thiosquaramide Catalyst.

Enantioselective imine reduction of dihydro-β-carbolines (DHBCs) is a reliable and powerful tool to construct bioactive chiral tetrahydro-β-carbolines (THBCs). Here, we report an efficient enantioselective imine reduction employing generated Fe-thiosquaramides (Fe-TSQs) and as asymmetric organometallic catalysts to produce chiral THBCs (-). The catalyst at 15 mol % was found to be suitable for the substrates with alkyl and aryl groups which afford corresponding chiral THBCs with excellent enantioselectivities (up to ee 99%).

Zn alleviated salt toxicity in Solanum lycopersicum L. seedlings by reducing Na transfer, improving gas exchange, defense system and Zn contents.

Soil secondary salinization is a serious menace that has significant influence on the sustainability of agriculture and threatens food security around the world. Zinc (Zn) as an essential plant nutrient associated with many physio-biochemical processes in plants and improve resistance against various abiotic stresses. The role of Zn in acclimation of Solanum lycopersicum L.

Corrigendum: Role of Promising Secondary Metabolites to Confer Resistance Against Environmental Stresses in Crop Plants: Current Scenario and Future Perspectives.

[This corrects the article DOI: 10.3389/fpls.2022.

Human primary chronic wound derived fibroblasts demonstrate differential pattern in expression of fibroblast specific markers, cell cycle arrest and reduced proliferation.

Introduction: Although wound refers to simple cut in the skin, most wounds don't heal because of the various local and systemic factors that lead to its complexity and chronicity. Thus, prior understanding of the status of the wound is necessary and methods that can differentiate between the healing and non-healing wounds at a much earlier stage is crucial for a successful treatment.

Methods: The current study aims at differentiating Acute Wound Fibroblasts (AWFs) and Chronic Wound Fibroblasts (CWFs) based on differential expression of fibroblast specific markers such as Vimentin and Alpha Smooth Muscle Actin (α-SMA) and compare its cell cycle and proliferation.

Role of Promising Secondary Metabolites to Confer Resistance Against Environmental Stresses in Crop Plants: Current Scenario and Future Perspectives.

Plants often face incompatible growing environments like drought, salinity, cold, frost, and elevated temperatures that affect plant growth and development leading to low yield and, in worse circumstances, plant death. The arsenal of versatile compounds for plant consumption and structure is called metabolites, which allows them to develop strategies to stop enemies, fight pathogens, replace their competitors and go beyond environmental restraints. These elements are formed under particular abiotic stresses like flooding, heat, drought, cold, etc.

TCCA-mediated oxidative rearrangement of tetrahydro-β-carbolines: facile access to spirooxindoles and the total synthesis of (±)-coerulescine and (±)-horsfiline.

Multi-reactive centered reagents are beneficial in chemical synthesis due to their advantage of minimal material utilization and formation of less by-products. Trichloroisocyanuric acid (TCCA), a reagent with three reactive centers, was employed in the synthesis of spirooxindoles through the oxidative rearrangement of various -protected tetrahydro-β-carbolines. In this protocol, low equivalents of TCCA were required to access spirooxindoles (up to 99% yield) with a wide substrate scope.

2D/2D Nanoarchitectured NbC/TiC MXene Heterointerface for High-Energy Supercapacitors with Sustainable Life Cycle.

Layered 2D/2D heterointerface composites experience interesting properties that greatly stimulate the recent surge in the attention as robust supercapacitor electrode materials, especially the MXene-based 2D/2D heterointerface for its robust energy storage compatibility. This report unveils a synergistically in situ prepared 2D/2D NbC/TiC MXene (NCTC) heterointerface nanoarchitecture by facile one-pot chemical etching. The methodology adopted enables the interconnected and simultaneous growth of MXenes exposing and retaining their active surfaces for enhanced ion diffusion pathways, charge storage dynamics, microstructural stability, and a noticeable potential window.

Research advances in the fabrication of biosafety and functional leather: A way-forward for effective management of COVID-19 outbreak.

With the recent events following the pandemic COVID-19, global awareness about the use of biosafety materials has been in raise. Leather industry being a major commodity-driven sector, its role in addressing the issues concerning the safe use of leather products has become inevitable for the sustainability of the industry. A significant number of researches have been conducted to fabricate bio-safe leather by incorporating different types of antimicrobial agents during leather manufacturing.

Bisphosphonate Therapy in the Management of Symptomatic Melorheostosis of Tibia.

Introduction: Melorheostosis is a rare sclerosing bone disease characterized by linear hyperostotic bone dysplasia with its radiological appearance as melting candle wax dripping by its side. It usually affects long bones, especially the lower limb. The exact cause of the disease has not been clearly explained though many theories are available.

Genomic characterization of Puccinia triticina using molecular marker technology.

Leaf rust, caused by Puccinia triticina, is the most common rust disease of wheat. The fungus is an obligate parasite capable of producing infectious urediniospores. To study the genetic structure of the leaf rust population 20 RAPD primers were evaluated on 15 isolates samples collected in Pakistan.