Over the past few decades, extensive research has explored the development of supportive scaffold materials for hepatic cell culture, to effectively mimic microenvironments. It is crucial for hepatic disease modeling, drug screening, and therapeutic evaluations, considering the ethical concerns and practical challenges associated with experiments. This review offers a comprehensive perspective on hepatic cell culture using bioscaffolds by encompassing all stages of hepatic diseases-from a healthy liver to fibrosis and hepatocellular carcinoma (HCC)-with a specific focus on matrix stiffness.
View Article and Find Full Text PDFChemosphere
January 2022
In this study, Polyphenols functionalized Graphitic Hematite Nanocomposite (PGHN) was used as an adsorbent to remove Caesium (Cs) ions from a simulated solution. The nanocomposite was produced by synthesizing iron oxide nanoparticles using orange peel extract (OPE) as the reducing and capping agent in the presence of graphite produced from sugarcane bagasse. The nanocomposite exhibited a scaly morphology and the mean particle size of rhombohedral structured hematite nanoparticles was found to be 148.
View Article and Find Full Text PDFCoronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To date, there is no effective therapeutic approach for treating SARS-CoV-2 infections. MicroRNAs (miRNAs) have been recognized to target the viral genome directly or indirectly, thereby inhibiting viral replication.
View Article and Find Full Text PDFThe waste water released from industries which contain pollutants like heavy metals, dyes and other toxic chemicals brings numerous harms to the ecosystem and humans. Nowadays the nanocomposites based technologies are effectively used for environmental remediation. In the present study, hexavalent chromium was removed from the industrial effluent using magnetite carbon nanocomposite.
View Article and Find Full Text PDFIron oxide nanoparticles synthesis is an expanding area of research due of their magnetic properties and possible applications in several novel technologies. FeONPs are indispensable in the biomedical field for diagnosis, treatments and drug delivery and in bioremediation applications. The synthesis route of nanoparticles is a major concern because biological methods are eco-friendly, and chemical methods are considered toxic.
View Article and Find Full Text PDFRadiation can be lethal at high doses, whereas controlled doses are useful in medical applications. Other applications include power generation, agriculture sterilization, nuclear weapons, and archeology. Radiation damages genetic material, which is reflected in genotoxicity and can cause hereditary damage.
View Article and Find Full Text PDFACS Appl Mater Interfaces
June 2021
Burn wounds are susceptible to microbial invasion from both resident and exogenous bacteria, which becomes a critical public health issue and causes substantial economic burden. There is a perceived demand to produce new antimicrobial wound dressings that hinder bacterial colonization while accelerating the healing process and hence would provide an improved standard of care for patients. Since ancient times, herbal extracts from medicinally important plants have extensively been used for treating burn injuries.
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