Publications by authors named "Sathi Paul"
Electrochemical cofactor recycling of bacterial microcompartments.
Proc Natl Acad Sci U S A
December 2024
Bacterial microcompartments (BMCs) are prokaryotic organelles that consist of a protein shell which sequesters metabolic reactions in its interior. While most of the substrates and products are relatively small and can permeate the shell, many of the encapsulated enzymes require cofactors that must be regenerated inside. We have analyzed the occurrence of an enzyme previously assigned as a cobalamin (vitamin B) reductase and, curiously, found it in many unrelated BMC types that do not employ B cofactors.
View Article and Find Full Text PDFBacterial microcompartments (BMCs) are prokaryotic organelles that consist of a protein shell which sequesters metabolic reactions in its interior. While most of the substrates and products are relatively small and can permeate the shell, many of the encapsulated enzymes require cofactors that must be regenerated inside. We have analyzed the occurrence of an enzyme previously assigned as a cobalamin (vitamin B) reductase and, curiously, found it in many unrelated BMC types that do not employ B cofactors.
View Article and Find Full Text PDFArticle Synopsis
- - Chickpeas are significantly affected by Fusarium wilt disease, with challenges in developing resistant varieties due to limited access to resistant genes from different cultivars.
- - Researchers discovered that the MYB78 transcription factor is crucial during the interaction between chickpeas and Fusarium, leading to successful transformation techniques for enhancing disease resistance in chickpeas.
- - The study found that while overexpressing CaMYB78 conferred resistance to the disease, it also disrupted anthocyanin production in flowers, highlighting its dual role in resistance and pigmentation regulation.
Defence response in plants and animals against a common fungal pathogen.
Curr Res Microb Sci
April 2022
Article Synopsis
- - Plant pathogens like *insert-pathogen-name* are emerging as significant threats to both human and animal health, with a focus on their impact on agriculture and economic loss.
- - This specific pathogen primarily affects plants but can also infect immunocompromised humans, raising concerns in the medical community.
- - The review will explore the innate immune responses in both plants and animals against this pathogen, aiming to uncover genetic and biochemical factors that could lead to effective antifungal treatments for humans.
Article Synopsis
- COVID-19, caused by the SARS-CoV-2 virus, continues to affect the world significantly, prompting intense research for effective treatments and the approval of several vaccines.
- The virus's ability to mutate, leading to variants that can evade immune responses, raises concerns about the long-term effectiveness of these vaccines.
- Researchers have identified a plant lectin, NTL-125, from Narcissus tazetta, which shows strong potential in inhibiting SARS-CoV-2 replication by binding to the virus’s spike protein, possibly serving as a promising antiviral therapy for COVID-19.
Unlabelled: Using 108 petroleum contaminated soil samples, this pilot study proposed a new analytical approach of combining visible near-infrared diffuse reflectance spectroscopy (VisNIR DRS) and portable X-ray fluorescence spectrometry (PXRF) for rapid and improved quantification of soil petroleum contamination. Results indicated that an advanced fused model where VisNIR DRS spectra-based penalized spline regression (PSR) was used to predict total petroleum hydrocarbon followed by PXRF elemental data-based random forest regression was used to model the PSR residuals, it outperformed (R(2)=0.78, residual prediction deviation (RPD)=2.
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