An iron metal-organic framework-based electrochemical sensor for identification of Bisphenol-A in groundwater samples.

Bisphenol A (BPA) is an endocrine disruptor that leaches into food and is significantly employed in food and beverage storage, and source water cycles. To ensure an outstanding and sustainable biosphere while safeguarding human health and well-being, BPA detection is essential, necessitating an efficient detection methodology. Here, we describe an easy-to-use, inexpensive, and overly sensitive electrochemical detector that uses Fe-MOF nanotextures for identifying BPA in groundwater.

An expeditious synthesis of 6,7-dihydrodibenzo[,][4,7] phenanthroline derivatives as fluorescent materials.

A rapid and efficient method has been developed for the synthesis of 13,14-dimethyl-6,7-dihydrodibenzo[,][4,7]phenanthroline derivatives (3a-d) through the Friedländer condensation of 2-aminoarylketone with 1,4-cyclohexanedione under solvent-free conditions using -toluenesulphonic acid. The synthetic utility of compounds 3a, 3b, and 3c was demonstrated by synthesizing compounds 6a-k Suzuki coupling, 8 by Buchwald-Hartwig amination, and 9a-b NBS bromination. Significantly, the emission band corresponding to the π-π* electronic transition of compounds 3a, 6a, 6d, 6f, and 8 showed a redshift with increasing polarity of the solvents.

Facile One-Pot Synthesis of Functionalized Quinoline-Fused Fluorescent Dihydro/Spiro-quinazolinone Derivatives.

A facile and efficient method has been developed for the synthesis of quinoline-fused fluorescent dihydro/spiro-quinazolinones. A plausible mechanism involving an acid-mediated enaminone intermediate is provided. The reaction proceeded using -toluene sulfonic acid as a green promoter.

DMSO-allyl bromide: a mild and efficient reagent for atom economic one-pot -allylation and bromination of 2°-aryl amines, 2-aryl aminoamides, indoles and 7-aza indoles.

A mixture DMSO-allyl bromide has been developed as a reagent for an atom economic one-pot -allylation and aryl bromination under basic conditions. Utilizing this reagent, -allylation-bromination of a number of 2°-aryl amines, aryl aminoamides, indoles, and 7-aza indoles has been achieved. The scope of the substrates and limitations, the synthetic utility of the products, and a plausible reaction mechanism have been proposed.

Chromone, A Privileged Scaffold in Drug Discovery: Developments in the Synthesis and Bioactivity.

Chromones are the class of secondary metabolites that broadly occur in the plant kingdom in a noticeable quantity. This rigid bicyclic system has been categorized "as privileged scaffolds in compounds" in medicinal chemistry. Their wide biological responses have made them an important moiety in a drug discovery program.

Microwave-Assisted -Allylation/Homoallylation-RCM Approach: Access to Pyrrole-, Pyridine-, or Azepine-Appended (Het)aryl Aminoamides.

A facile and diversity-oriented approach has been developed for the synthesis of pyrrole-, pyridine-, or azepine-appended (het)aryl aminoamides via the -allylation/homoallylation-ring-closing metathesis (RCM) strategy. Microwave condition was efficiently utilized for -allylation of (het)aryl aminoamides to synthesize di-, tri-, and tetra-allyl/homoallylated RCM substrates in good yields. All of the RCM substrates were successfully converted to respective pyrroles , ,, ,, pyridines , , and azepines , via RCM.

Design of a potent anticancer lead inspired by natural products from traditional Indian medicine.

Among the plant constituents of Walp., acteoside, martinoside, and osmanthuside β6 interact with ROCK, a drug target for cancer. In this study, aglycone fragments of these plant constituents (caffeic acid, ferulic acid, and -coumaric acid) along with the homopiperazine ring of fasudil (standard ROCK inhibitor) were used to design hybrid molecules.