Publications by authors named "Sateesh Reddy"
Article Synopsis
- The study focuses on the increase in cases of COVID-19 associated mucormycosis (CAM) during the second wave of COVID-19 in India, mainly affecting patients with diabetes.
- Conducted at Noble Hospital in Pune between April 2020 and August 2021, the research involved 59 CAM patients, revealing high mortality rates linked to factors like uncontrolled diabetes and high COVID-19 CT severity scores.
- Treatment success was achieved through surgical debridement and antifungal therapy, with 74.6% of patients recovering, highlighting the urgent need for appropriate steroid use in COVID-19 treatment to prevent complications like CAM.
Article Synopsis
- The study focuses on using a technique called in situ ReactIR to monitor and quantify specific compounds from medicinal plants, which is important for quality control in the herbal industry.
- Researchers extracted piperine from black pepper and curcumin from turmeric using different solvents, while tracking the extraction progress with FTIR technology.
- This is the first time that real-time quantification and structural analysis of these compounds during extraction have been reported, showcasing a method that optimizes extraction parameters.
Cytokine release syndrome (CRS) or cytokine storm is thought to be the cause of inflammatory lung damage, worsening pneumonia and death in patients with COVID-19. Steroids (Methylprednislone or Dexamethasone) and Tocilizumab (TCZ), an interleukin-6 receptor antagonist, are approved for treatment of CRS in India. The aim of this study was to evaluate the efficacy and safety of combination therapy of TCZ and steroid in COVID-19 associated CRS.
View Article and Find Full Text PDFThis study depicts the use of a fiber-optic coupled Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) probe for the in-depth study of arene diazonium salt formation and their utilization in the Heck-Matsuda reaction. The combination of these chemical reactions and in situ IR spectroscopy enabled us to recognize the optimum parameters for arene diazonium salt formation and to track the concentrations of reactants, products and intermediates under actual reaction conditions without time consuming HPLC analysis and the necessity of collecting the sample amid the reaction. Overall advantages of the proposed methodology include precise reaction times as well as identification of keto enol tautomerization in allylic alcohols supporting the 'path a' elimination mechanism in the Heck-Matsuda reaction.
View Article and Find Full Text PDFA sequential Pd-mediated multi-component reaction followed by Suzuki or Heck or Sonogashira coupling in a single pot has been developed for the synthesis of functionalized pyrroles as potential inhibitors of PDE4.
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