Publications by authors named "Satbir S Thakur"
Ki67 is a commonly used marker of cancer cell proliferation, and has significant prognostic value in breast cancer. In spite of its clinical importance, assessment of Ki67 remains a challenge, as current manual scoring methods have high inter- and intra-user variability. A major reason for this variability is selection bias, in that different observers will score different regions of the same tumor.
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- The ING1 gene is important for helping cells die when they’re damaged, which is a good thing because it can prevent cancer.
- Scientists found that a part of this gene, called p33ING1b, can move to a part of the cell called the mitochondria when the cell is hurt, and this can make cancer cells die better.
- In patients with a type of cancer called oral squamous cell carcinoma, higher levels of p33ING1b in their cancer cells were linked to better survival, especially when they got radiation treatment along with it.