Detrimental effects of chronic sugar-sweetened carbonated soft drink consumption on inflammatory response and the size of apical periodontitis: An animal-based study.

Aim: This study aimed to evaluate the effects of chronic consumption of two sugar-sweetened carbonated soft drinks - one containing caffeine (Coca-Cola®) and one without (Sprite®) - on the progression of periapical lesions and the levels of pro-inflammatory cytokines in rats.

Methodology: Twelve Wistar rats were divided into three groups (n = 4): Control group, Coca-Cola group and Sprite group. The rats in Coca-Cola and Sprite groups were given ad libitum access to their respective soft drinks for 3 months, while the Control group received filtered water.

Gender analysis of editorial boards and authorship in leading endodontics journals.

Aim: To evaluate the presence of women on editorial boards and as authors in leading global endodontics journals from 2018 to 2023.

Methodology: The selection of journals was based on the impact factor from Journal Citation Reports (JCR) and CiteScore 2022, with criteria of JCR above 1 and CiteScore above 1.5.

Evaluation of a potential bidirectional influence of metabolic syndrome and apical periodontitis: An animal-based study.

Aim: This study aimed to explore the possible bidirectional interrelations between fructose-induced metabolic syndrome (MS) and apical periodontitis (AP).

Methodology: Twenty-eight male Wistar rats were distributed into four groups (n = 7, per group): Control (C), AP, Fructose Consumption (FRUT) and Fructose Consumption and AP (FRUT+AP). The rats in groups C and AP received filtered water, while those in groups FRUT and FRUT+AP received a 20% fructose solution mixed with water to induce MS.

Success rate of direct pulp capping on permanent teeth using bioactive materials: a systematic review and meta-analysis of randomized clinical trials.

This systematic review and meta-analysis aimed to evaluate the success rate of direct pulp capping (DPC) on permanent teeth, comparing the use of MTA with calcium hydroxide and calcium silicate-based cements. A systematic search was carried out in 4 databases until July 2023. The selection was based on PICOS criteria and only randomized clinical trials were included.

Micro-computed tomographic evaluation of dentinal microcracks in response to progressive taper enlargement in root canals of maxillary molars.

Aim: To investigate the development of dentinal microcracks resulting from the progressive enlargement of the buccal canals of maxillary molars with and without the MB2 canal employing instruments with the same tip and four different tapers.

Methodology: Twenty maxillary molars with (n = 10) and without (n = 10) the MB2 canal underwent micro-CT scanning. Their mesiobuccal and distobuccal canals were sequentially enlarged using nickel-titanium instruments with sizes 25/.

Dental Pathophysiology of Odontogenic Sinusitis: Endodontic Infections.

Bacterial odontogenic sinusitis (ODS) arises from maxillary dental issues or oral procedures, and affects at least the maxillary sinuses, with or without other paranasal sinus involvement. It has been historically underreported, in contrast to more recent findings attributing 25-40% of chronic maxillary sinusitis to dental causes. Endodontic infections represent one of the most common causes of ODS.

Apical periodontitis as an aggravating factor for the severity of rheumatoid arthritis: An animal study.

Aim: The present study investigated the influence of apical periodontitis (AP) on the severity of rheumatoid arthritis (RA) using a Wistar rat model.

Methodology: Forty male Wistar rats were distributed across four groups (n = 10) based on the induction of RA and AP: Control, RA, AP, and RA + AP. RA was induced through two immunisations with type II collagen emulsified in incomplete Freund's adjuvant, followed by one immunisation with complete Freund's adjuvant.

Effects of increasing instrument size and taper on the disinfection and shaping of mandibular incisors.

This study assessed canal preparation effects on disinfection and dentin preservation. Thirty mandibular incisors were paired into two experimental groups (n = 10). Following contamination, the initial microbial sample was collected.

Chronic alcohol and nicotine consumption as catalyst for systemic inflammatory storm and bone destruction in apical periodontitis.

Aim: To assess the periapical alveolar bone pattern and the serum levels of proinflammatory cytokines, biochemical markers and metabolites in rats subjected to chronic alcohol and nicotine consumption and induced apical periodontitis.

Methodology: Twenty-eight male Wistar rats were divided into four groups: Control, Alcohol, Nicotine and Alcohol+Nicotine. The alcohol groups were exposed to self-administration of a 25% alcohol solution, while the other groups were given only filtered water.

Effect of the progressive taper enlargement of buccal root canals of three-rooted maxillary molars: A stepwise micro-CT study.

This study evaluated unprepared canal areas, volume of dentine removal, and dentine thickness after the progressive enlargement of the buccal canals of 22 maxillary molars, with and without the MB2, using instruments with the same tip size (0.25 mm) but 4 different tapers (0.03, 0.

Association between Apical Periodontitis and Chronic Diseases: An Umbrella Review.

Introduction: To assess the methodological quality of systematic reviews (SRs) that evaluated the association between apical periodontitis (AP) and chronic diseases.

Materials And Methods: A systematic search was performed in the databases PubMed, Virtual Health Library, Scopus, Cochrane Library, Embase, Web of Science and Open Grey. SRs that evaluated the association between any chronic disease and AP, and that had performed a valid risk of bias assessment were included.

Volumetric changes in root canal sealers in ex vivo and a novel animal model approach.

Aim: This study aimed to evaluate the volumetric change of root canal sealers through micro-computed tomographic analysis using a novel in vivo model and to compare the results with those obtained using an ex vivo test.

Methodology: Eighteen single-rooted teeth were cut to 5 mm length from the root apex. The root canals were uniformly enlarged and filled with EndoSequence BC Sealer or AH Plus Jet root canal sealers.

What Is the Microbial Profile in Persistent Endodontic Infections? A Scoping Review.

Introduction: This scoping review aimed to map the evidence about the microbiota found in persistent endodontic infections.

Methods: The study protocol was prospectively registered and is available at https://osf.io/3g2cp.

pH influences the volumetric change of calcium silicate- and epoxy resin-based root canal sealers: An ex vivo micro-CT study.

This study assessed the influence of pH variation on the volumetric change of EndoSequence BC Sealer compared to AH Plus Jet. Eighteen single-rooted teeth were uniformly prepared and filled with one of the sealers. After 24-h storing, samples were scanned in a micro-CT device.

Impact of Minimally Invasive Endodontic Procedures on the Development of Dentinal Microcracks.

Introduction: To evaluate the impact of root canal preparation in teeth with ultraconservative access cavities (UltraAC) on the development of dentinal microcracks using a nondestructive longitudinal micro-computed tomography (micro-CT) imaging experimental model. Root canal preparation in teeth with traditional access cavities (TradAC) was used as control.

Methods: Forty mandibular molars were scanned in a micro-CT device, anatomically matched, and distributed into 4 groups according to the type of access cavity and instrumentation system: traditional/Reciproc (TradAC/RC), traditional/XP-endo Shaper (TradAC/XP), ultraconservative/Reciproc (UltraAC/RC), and ultraconservative/XP-endo Shaper (UltraAC/XP).

Photodynamic therapy for root canal disinfection in endodontics: an umbrella review.

To evaluate and synthesize the evidence from the individual reviews that evaluated the efficacy of PDT therapy in root canal disinfection by undertaking an umbrella review. The protocol of the review was registered in the PROSPERO database under number CRD42021214056. The literature search was conducted using the following electronic databases: PubMed, Scopus, Web of Science, BVS, Cochrane Database of Systematic Reviews, Embase, and Epistemonikos, from inception to July 2021.

The Impact of TruNatomy and ProTaper Gold Instruments on the Preservation of the Periradicular Dentin and on the Enlargement of the Apical Canal of Mandibular Molars.

Introduction: This study aimed to evaluate the preservation of periradicular dentin and the enlargement of the apical canal of mandibular molars with TruNatomy (Dentsply Sirona, Ballaigues, Switzerland) and ProTaper Gold (Dentsply Sirona) instruments.

Methods: Twenty mandibular molars were scanned in a micro-computed tomographic device, anatomically paired, and distributed into 2 groups (n = 10). In the ProTaper Gold group, mesial and distal canals were prepared up to F2 (25/.

Effect of passive ultrasonic irrigation on hard tissue debris removal: a systematic review and meta-analysis.

Accumulated hard tissue debris (AHTD) in root canal irregularities may negatively impact adequate root canal disinfection. In light of this, the efficacy of passive ultrasonic irrigation (PUI) to reduce AHTD has been largely studied in in vitro studies, which have adopted different analytic methods of varying accuracy to determine the extent of AHTD more correctly. Therefore, the aim of this study was to compare how well PUI and non-activated irrigation (NAI) systems perform in reducing AHTD during final irrigation protocols, based exclusively on studies whose analyses used microCT scanning.

Ten years of minimally invasive access cavities in Endodontics: a bibliometric analysis of the 25 most-cited studies.

Objectives: This study aimed to analyze the main features of the 25 most-cited articles in minimally invasive access cavities.

Materials And Methods: An electronic search was conducted on the Clarivate Analytics' Web of Science 'All Databases' to identify the most-cited articles related to this topic. Citation counts were cross-matched with data from Elsevier's Scopus and Google Scholar.

Influence of the use of chelating agents as final irrigant on the push-out bond strength of epoxy resin-based root canal sealers: A systematic review.

This systematic review (PROSPERO - CRD42020150722) was performed to answer the following question: Does the use of chelating agents affect the dislodgment resistance of epoxy resin-based root canal sealers? A search was conducted in PubMed, EMBASE, Scopus, LILACS and Web of Science, hand searching of two endodontic journals and grey literature until September 2020. Extracted data included: teeth used, sample size, root canal preparation, irrigant, chelating solution, neutralisation solution, type of resin-based sealer and obturation approach, storage method and duration, root third and slice thickness, plunger dimension and loading direction and the push-out testing parameters and values. The search retrieved a total of 2.

Antibacterial Efficacy of Triple Antibiotic Medication With Macrogol (3Mix-MP), Traditional Triple Antibiotic Paste, Calcium Hydroxide, and Ethanol Extract of Propolis: An Intratubular Dentin Ex Vivo Confocal Laser Scanning Microscopic Study.

Introduction: This study aimed to assess the effectiveness of antibacterial activity of medications used in regenerative endodontic treatment.

Methods: Sixty-seven dentin cylinders of single-rooted teeth were contaminated with a culture of Enterococcus faecalis (ATCC 29212; American Type Culture Collection, Manassas, VA) for 5 days. Samples were divided into 1 control group and the following experimental groups according to the medication applied: traditional triple antibiotic paste (TAP), clindamycin-modified TAP (mTAP), triple antibiotic medication with macrogol (3Mix-MP), clindamycin-modified 3Mix-MP (m3Mix-MP), calcium hydroxide (CH), and ethanol extract of propolis (EEP).

Shaping ability and apical debris extrusion after root canal preparation with rotary or reciprocating instruments: a micro-CT study.

Objectives: The aim of this study was to evaluate the shaping ability of the TruShape and Reciproc Blue systems and the apical extrusion of debris after root canal instrumentation. The ProTaper Universal system was used as a reference for comparison.

Materials And Methods: Thirty-three mandibular premolars with a single canal were scanned using micro-computed tomography and were matched into 3 groups ( = 11) according to the instrumentation system: TruShape, Reciproc Blue and ProTaper Universal.

Influence of variations in the environmental pH on the solubility and water sorption of a calcium silicate-based root canal sealer.

Aim: To evaluate the influence of pH variation on the solubility and water sorption of a premixed calcium silicate-based root canal sealer (EndoSequence BC Sealer) compared to the gold standard based on epoxy resin (AH Plus Jet) after immersion in distilled water and phosphate-buffered saline (PBS).

Methodology: Solubility and water sorption were evaluated after immersion in distilled water or PBS at several pHs (5, 7 and 12) and the values were calculated as percentages of the original mass after 24 h, 7 and 30 days of immersion. The crystalline structures present in the sealers and surface precipitates were assessed by X-ray diffraction.

Bacterial Reduction in Oval-Shaped Root Canals After Different Irrigant Agitation Methods.

Objective: This study aimed to assess the antibacterial effect of Easy Clean®, passive ultrasonic irrigation and sonic irrigation against Enterococcus faecalis biofilm in oval-shaped canals.

Methods: Fifty-five extracted human teeth with similar dimensions were selected. Access cavities were prepared and the root canals were instrumented using Wave One® Primary files (25.

Antibacterial, biological, and physicochemical properties of root canal sealers containing chlorhexidine-hexametaphosphate nanoparticles.

Objective: The aim of this study was to evaluate the influence of the incorporation of chlorhexidine-hexametaphosphate nanoparticles (CHX-HMP NPs) on antibacterial, cytotoxic and physicochemical properties of AH Plus (AH), MTA Fillapex (MTA) and Pulp Canal Sealer (PCS).

Methods: The NPs were synthesized and characterized by Scanning Electron Microscopy (SEM), Dynamic Light Scattering (DLS), zeta potential, Atomic Force Microscopy (AFM) and Energy-Dispersive X-ray Spectroscopy (EDS). The incorporation was made by weight, 2% and 5% of NPs.