Publications by authors named "Saskia V Pante"

Aim: To do justice to the need for planetary health in medical education, these are the aims of the online elective course "Planetary Health in Medical Education" (ME elective):1. Enable students to plan and realize their own course sessions on planetary health;2. Encourage communication among university medical faculties regarding planetary health in medical education;3.

View Article and Find Full Text PDF

Introduction: Examinations are a central element of the medical curriculum: they contribute significantly to the quality assurance of medical training and subsequent medical care. In order to meet the high expectations placed on examinations in terms of content, legal and organizational aspects, continuous quality assurance measures are necessary. The aim of this paper was to record and analyze the quality assurance measures implemented at the medical faculty of Heidelberg.

View Article and Find Full Text PDF

Due to the corona pandemic, we conducted the Heidelberg module of the Master of Medical Education (MME) study program, which focuses on teaching and assessment of communicative and interpofessional skills, digitally for the first time. We outsourced the teaching to a pre-module phase in the weeks upfront. During the module week, the lecturers picked up again and deepened the topics and the participants created, revised and simulated a virtual OSCE course.

View Article and Find Full Text PDF

Medical education has the responsibility to react to developments and changing demands in healthcare. This implies the need for experts in the area of medical education as well as nationally coordinated initiatives. An innovative model based on trans-institutional cooperation and nationwide consensus for establishing a master's degree course in Medical Education (MME) and long-term results are presented here to other countries and other programs, facing similar challenges.

View Article and Find Full Text PDF

The increasing significance of didactic aspects in medical education has also led to the development of special postgraduate programs. Completion rates represent an important outcome criterion for these programs of study. Up to today, detailed studies on what factors influence these completion rates have been lacking.

View Article and Find Full Text PDF
Article Synopsis
  • SIRT1 is a key factor in cellular stress response and has a complex role in cancer, acting as a tumor suppressor in some cases while promoting cancer in others, especially in chronic myeloid leukemia.
  • In acute myeloid leukemia (AML), SIRT1 is overexpressed in certain cells due to mutations associated with active signaling pathways, particularly those involving FLT3.
  • Targeting SIRT1, either through drugs or RNA interference, can inhibit AML cell growth and enhance the effectiveness of tyrosine kinase inhibitors and chemotherapy by restoring p53 activity, making it a potential therapeutic target for resistant AML cases.
View Article and Find Full Text PDF

MOZ-TIF2 is a leukemogenic fusion oncoprotein that confers self-renewal capability to hematopoietic progenitor cells and induces acute myelogenous leukemia (AML) with long latency in bone marrow transplantation assays. Here, we report that FLT3-ITD transforms hematopoietic cells in cooperation with MOZ-TIF2 in vitro and in vivo. Coexpression of FLT3-ITD confers growth factor independent survival/proliferation, shortens disease latency, and results in an increase in the number of leukemic stem cells (LSC).

View Article and Find Full Text PDF