Secondary Resections and Survival After Breast-Conserving Surgery in Breast Cancer Patients: A Cancer Registry-Based Cohort Study.

Breast cancer remains the most common malignancy in women, and breast-conserving surgery (BCS) with adjuvant radiotherapy is a standard treatment for early-stage disease. This study assessed the impact of positive surgical margins and secondary surgeries on local recurrence rates and patient outcomes. In this retrospective tumor registry-based study, 24,450 women were eligible for analysis.

Clinical characteristics, metastasis patterns, and treatment outcomes of HER2-low breast cancer.

Breast cancer (BC) is a heterogeneous disease, traditionally classified by hormone receptor and HER2 (human epidermal growth factor receptor 2) status. HER2-low, characterized by low HER2 expression without gene amplification, recently gained attention. While new therapies are promising, its clinical significance remains unclear.

Acute respiratory tract infections during the first 6 years of life - results from the German birth cohort study LoewenKIDS.

Objectives: Acute respiratory tract infections (ARIs) often occur in early childhood and are mostly self-limited. However, they impose a high socioeconomic burden and can be associated with chronic diseases later in life. To date, data on self-reported ARIs beyond infancy are limited.