Publications by authors named "Saskia Rudat"

In acute myeloid leukemia (AML), leukemogenesis depends on cell-intrinsic genetic aberrations and thus, studies on AML require investigations in an in vivo setting as provided by patient derived xenografts (PDX) models. Here we report that, next to leukemic cell characteristics, recipient sex highly influences the outgrowth of AML cells in PDX models, with females being much better repopulated than males in primary as well as secondary transplantation assays. Testosterone may be the more important player since, strikingly, better engraftment was seen in castrated versus control male recipients, while ovariectomy did not significantly impair engraftment in females.

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While oncogenes promote tumorigenesis, they also induce deleterious cellular stresses, such as apoptosis, that cancer cells must combat by coopting adaptive responses. Whether tumor suppressor gene haploinsufficiency leads to such phenomena and their mechanistic basis is unclear. Here, we demonstrate that elevated levels of the anti-apoptotic factor, CASP8 and FADD-like apoptosis regulator (CFLAR), promotes apoptosis evasion in acute myeloid leukemia (AML) cells haploinsufficient for the cut-like homeobox 1 (CUX1) transcription factor, whose loss is associated with dismal clinical prognosis.

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Article Synopsis
  • The POT1 protein is part of a shelterin complex that regulates and protects telomeres, and mutations in POT1 are linked to melanoma and other cancers.
  • A study identified a novel germline POT1 variant (p.I78T) in families with melanoma, involving detailed pedigree analysis and genetic testing among participants of Jewish descent.
  • The p.I78T variant disrupts POT1's binding to telomeres and is associated with UV mutations and additional somatic mutations in melanoma patients, suggesting it should be screened for in melanoma families.
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