Publications by authors named "Saskia H J Renkens"
Mol Ther Oncolytics
March 2022
Article Synopsis
- - The study investigates how cancer cell energy metabolism, particularly NAD+ levels, influences the effectiveness of oncolytic viruses like reovirus in treating multiple myeloma.
- - Researchers found that lower NAD+ levels, from inhibiting the enzyme NAMPT, made multiple myeloma cells more susceptible to reovirus-induced killing, especially in cells with active p53 and a preference for mitochondrial metabolism.
- - The combination treatment of reovirus and NAD+ depletion led to significant mitochondrial dysfunction and cell death in specific myeloma cells, indicating that targeting NAD+ levels could enhance oncolytic virus therapies in multiple myeloma patients.
