Publications by authors named "Sasiwimon Utama"
Int J Mol Sci
August 2024
Article Synopsis
- - Vascular Ehlers-Danlos syndrome (vEDS) is a serious connective tissue disorder marked by skin elasticity issues, joint hypermobility, and risks of deadly vascular ruptures due to specific collagen III mutations.
- - The study investigated using antisense oligonucleotides (ASOs) to modify pre-mRNA and bypass these mutations, leading to successful excision of specific exons (10 and 15) and increased collagen III expression in patient fibroblasts.
- - Although the ASOs effectively skipped the target exons, the resulting collagen III showed problems with extracellular matrix formation, indicating that post-translational modifications are critical to proper collagen assembly and raising questions about the approach's therapeutic potential. *
