Current Scenario in Associating Clinical COVID-19 Biomarkers for Developing Surveillance Platforms.

The novel coronavirus that caused the epidemic and pandemic resulting in the acute respiratory illness known as coronavirus disease 2019 (COVID-19) has plagued the world. This is unlike other coronavirus outbreaks that have occurred in the past, such as Middle East respiratory syndrome (MERS) or severe acute respiratory syndrome (SARS). COVID-19 has spread more quickly and posed special challenges due to the lack of appropriate treatments and vaccines.

Assessing drywell designs for managed aquifer recharge via canals and repurposed wells.

This study explores innovative drywell designs for managed aquifer recharge (MAR) in agricultural settings, focusing on smaller diameter and deeper drywells, including the repurposing of dried or abandoned wells. Numerical simulations assessed the impact of drywell diameter (5-120 cm), depth (15-55 m), screen height, and subsurface heterogeneity on infiltration (I) and recharge (R) volumes over a one-year period under constant head conditions. Results indicate that smaller diameter drywells can effectively infiltrate and recharge significant water volumes.

Prospective observational study of FKRP-related limb-girdle muscular dystrophy R9: A GRASP consortium study.

Objective: Limb-girdle muscular dystrophy R9 (LGMDR9, formerly known as LGMD2I), caused by variants in the fukutin-related protein (FKRP) gene leads to progressive muscle weakness of the shoulder and pelvic limb-girdles and loss of motor function over time. Clinical management and future trial design are improved by determining which standardized clinical outcome assessments (COA) of function are most appropriate to capture disease presentation and progression, informing endpoint selection and enrollment criteria. The purpose of our study was to evaluate the cross-sectional validity and reliability of clinical outcome assessments in patients with FKRP-related LGMDR9 participating in the Genetic Resolution and Assessments Solving Phenotypes in LGMD (GRASP) natural history study.

Triggering the Interplay of sp-sp Carbon-Assisted Sustained Tribofilm via Two-Dimensional Surface Modulation for Exceptional Wear Resistance of Steel Surfaces.

The relentless wear and friction of steel-based moving machinery have created ongoing challenges that hinder their industrial applications. One promising solution is the use of reduced graphene oxide (rGO) as a lubricant due to its excellent mechanical strength and promising tribological properties. However, its tendency to self-agglomerate presents a major hurdle for its practical use.

Nutrition and oral health-related quality of life (OHRQoL) in older adults: a systematic review and meta-analysis.

Background: Understanding the interplay between nutrition and oral health-related quality of life (OHRQoL) in older adults is crucial amidst the global aging population. This systematic review and meta-analysis aimed to explore this association, recognizing the growing prevalence of older individuals and the imperative of addressing their health needs for enhanced well-being.

Materials And Methodology: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, relevant studies were identified through electronic database searches and manual screening.

Exploring the ancient roots and modern global brews of tea and herbal beverages: A comprehensive review of origins, types, health benefits, market dynamics, and future trends.

Tea, a culturally significant beverage, originated around 2700 B.C. in ancient Chinese civilization, with a profound understanding of its therapeutic properties.

Medicinal Plants Derived Green Carbon Dots: Synthesis, Characterization and Their Potential Applications in Cancer Therapy.

Objective: This review aims to explore the synthesis, characterization, and potential applications of carbon dots (CDs) derived from medicinal plants for cancer prevention, highlighting their role as a promising alternative in nanotechnological approaches.

Methods: A comprehensive literature search was conducted to gather information on the synthesis methods, complex matrices, characterization techniques, and potential applications of CDs derived from medicinal plants in cancer therapy.

Result: Carbon dots (CDs) have emerged as a subject of significant interest due to their favorable chemical and biological properties.

The Influence of Material Properties and Wall Thickness on Predicted Wall Stress in Ascending Aortic Aneurysms: A Finite Element Study.

Purpose: Finite element analysis (FEA) has been used to predict wall stress in ascending thoracic aortic aneurysm (ATAA) in order to evaluate risk of dissection or rupture. Patient-specific FEA requires detailed information on ATAA geometry, loading conditions, material properties, and wall thickness. Unfortunately, measuring aortic wall thickness and mechanical properties non-invasively poses a significant challenge, necessitating the use of non-patient-specific data in most FE simulations.

Bioinspired Hydrophobicity via Temperature-Induced Phase Separation of Beeswax: A Pathway for Developing Cellulose Nanofiber-Based Adsorbents for the Removal of Conventional Tetracycline Tablets.

Cellulose nanofiber-based aerogels (CNFAs) hold immense promise across diverse fields, but their innate hydrophilicity and structural fragility in water have constrained their utility in water purification. This study introduces a green approach to induce hydrophobicity into CNFAs via thermally induced phase separation (TIPS) of beeswax, which was adhered to the nanofiber by hydrogen bonding and hydrophobic-hydrophobic interactions. The fabricated aerogel was characterized by using FTIR, SEM, XRD, TGA, contact angle, BET, and compression test.

Impact of floods and landslides on rhizosphere bacterial communities: a high-throughput 16S rRNA gene sequencing study.

This study investigates the diversity and composition of soil bacterial communities in the rhizosphere of Attapadi and Nelliyampathy, prominent hill stations in Palakkad district, Kerala, India. The persistent flooding and landslides in 2018 and 2019 significantly impacted agricultural productivity in these regions. Utilizing high-throughput 16S rRNA gene sequencing (Illumina MiSeq), we conducted a comprehensive analysis of soil samples.

Microfluidic measurement of the size and shape of lipid-anchored proteins.

The surface of a cell is crowded with membrane proteins. The size, shape, density, and mobility of extracellular surface proteins mediate cell surface accessibility to external molecules, viral particles, and other cells. However, predicting these qualities is not always straightforward, even when protein structures are known.

Treatment of Type 2 Diabetes Mellitus in Advanced Chronic Kidney Disease for the Primary Care Physician.

Diabetes mellitus (DM) is a common cause of chronic kidney disease (CKD), leading to the need for renal replacement therapy (RRT). RRT includes hemodialysis (HD), peritoneal dialysis (PD), kidney transplantation (KT), and medical management. As CKD advances, the management of DM may change as medication clearance, effectiveness, and side effects can be altered due to decreasing renal clearance.

Architectural Decoration of Bioleached NiFeP Surfaces by CoO Flowers for Efficient Electrocatalytic Hydrogen Generation.

In the quest for sustainable hydrogen production via water electrolysis, the development of high-performance, noble-metal-free catalytic systems is highly desired. Herein, we proposed an innovative strategy for the development of an electrocatalyst by refining the surface characteristics of a NiFeP alloy through microbiological techniques and subsequent enrichment of active sites by tailoring 3D hierarchical flower-like structures with intact and interconnected two-dimensional (2D) CoO. The resultant 3D CoO@NiFeP-5/24h has a porous structure comprised of intercrossed nanoparticles covering the entirety of the catalytic surface.

Triggering Redox Active Sites Through Electronic Structure Modulation in rGO Encapsulated Mixed Transition Metal Oxides Hybrid for Alkaline Hydrogen Evolution.

Designing and developing noble-metal-free catalysts are of current interest in clean hydrogen generation via water splitting. As carbonaceous species are ideal choices as templates for various electrocatalysis, an improved synthetic route and an in-depth understanding of their electrochemical performance are essential. Herein, we have investigated the catalytic performance of rGO-encapsulated Mn and V mixed oxide hybrid structures (MVG) on a NiFeP matrix, focusing on their potential for catalyzing hydrogen evolution in an alkaline environment.

One Health, One Future: A Unified Approach to a Balanced Ecosystem.

In the past few decades, disease spillovers between humans and wildlife have increased in both frequency and severity [...

Investigating the association between tobacco use and oral health among security guards at a tertiary healthcare centre in New Delhi: a cross-sectional study.

Background: Tobacco usage is a major global public health concern, contributing to millions of deaths annually. This study focuses on security guards, an occupational group facing unique challenges, to investigate tobacco prevalence, usage patterns, and associated oral health risks.

Methods: A cross-sectional study was conducted among security guards at a Tertiary Health Care Centre, from October 2022 to February 2023.

Husband's involvement in utilization of maternal health services by their spouse in district Rohtak, Haryana.

Introduction: Husband and wife as a couple are fully responsible for their current and future. In our society, the husband is mostly responsible for making the decision regarding any expenses. In India, there is a need to reduce the maternal mortality rate, and Husband's involvement in antenatal care could be a key to success as it will enable them to support their partner in adequate preparation for birth and to utilize emergency obstetric care early if complications arise.

Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics.

Irrespective of medical technology improvements, cancer ranks among the leading causes of mortality worldwide. Although numerous cures and treatments exist, creating alternative cancer therapies with fewer adverse side effects is vital. Since ancient times, plant bioactive compounds have already been used as a remedy to heal cancer.

Comparison of Transesophageal Echocardiography Probe as Surface Probe with Vascular Probe During Right Internal Jugular Vein Catheterization in Cardiac Surgeries.

Context: USG vascular probe and TEE probe can help during central venous catheterization (CVC) and can confirm the location of guide wire in the neck vessels. We proposed this study, as there are only few studies comparing between TEE probe as surface probe and USG vascular probe for right IJV cannulation.

Aims: To compare the TEE probe as a surface probe and USG vascular probe during right IJV catheterization in cardiac surgeries.

Direct ophthalmoscopy as a screening tool to study retinal vascular changes in acute mountain sickness in response to recent ascent to high altitude: A pilot study.

Background Advanced diagnostics are not easily accessible in austere topographical locations. We documented retinal changes in patients with acute mountain sickness (AMS+) and compared these with asymptomatic individuals (AMS-) with recent induction into high altitude using direct ophthalmoscopy as a screening tool. Methods We evaluated 97 individuals (43 AMS- and 54 AMS+) who were inducted to an altitude 3800 m above sea level by direct ophthalmoscopy after pupillary dilatation, on day 2 of arrival.

CD63 sorts cholesterol into endosomes for storage and distribution via exosomes.

Extracellular vesicles such as exosomes are now recognized as key players in intercellular communication. Their role is influenced by the specific repertoires of proteins and lipids, which are enriched when they are generated as intraluminal vesicles (ILVs) in multivesicular endosomes. Here we report that a key component of small extracellular vesicles, the tetraspanin CD63, sorts cholesterol to ILVs, generating a pool that can be mobilized by the NPC1/2 complex, and exported via exosomes to recipient cells.

Anxiety and depression among couples undergoing treatment for infertility with assisted reproductive techniques at an Indian centre.

Background Infertility and its treatment are frequently associated with psychological distress. We assessed the prevalence of anxiety and depression in couples undergoing treatment for infertility with assisted reproductive techniques (ARTs). Methods We included 160 married couples undergoing treatment for infertility at an ART centre.