Publications by authors named "Sasidhar Gunturu"

Article Synopsis
  • Tobacco smoke exposure (TSE) is a significant public health issue affecting both smokers and those around them, particularly children, and is associated with serious neuropsychiatric conditions that degrade quality of life.* -
  • Analysis of data from the National Survey of Children's Health revealed that 12.9% of children experienced TSE, with a higher prevalence among males and lower-income families, and certain racial/ethnic backgrounds being more affected.* -
  • Around 36.4% of youths with TSE developed at least one neuropsychiatric condition, with anxiety, ADHD, and learning disabilities being the most common; differences in prevalence were observed among genders and racial backgrounds.*
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Understanding the association between initial experimentation with a tobacco product and subsequent patterns of tobacco use among youth is important to informing prevention activities for youth in the US. We conducted an online survey from August to October 2017 among youth aged 13-18 years. The current analysis focused on respondents reporting initial experimentation with any tobacco product (n = 2,022).

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Digital therapeutics have evolved rapidly with technological advances in healthcare. Despite their increasing use, gaps remain in understanding their regulatory frameworks, integration, and efficacy for conditions like substance use disorder, insomnia, attention deficit hyperactivity disorder, and post-traumatic stress disorder. This study evaluates FDA-approved digital therapeutics and explores their potential to revolutionize psychiatric treatments amid ongoing technological and regulatory changes.

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To analyze contemporary trends of dementia and dementia-related mortality in the United States between 1999 and 2020 categorized by demographic and regional attributes. A retrospective cohort analysis was conducted using mortality data from individuals aged 35 years to ≥85 years, where dementia/Alzheimer disease was recorded as a contributing or underlying cause of death. Data were extracted from the US Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research database for the years 1999-2020.

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Article Synopsis
  • Lennox-Gastaut syndrome (LGS) is a severe form of epilepsy mainly affecting children under eight, characterized by multiple seizure types and challenges in diagnosis.
  • It often leads to cognitive impairment and intellectual disabilities, complicating treatment due to the syndrome's complexity and associated psychiatric issues.
  • A case study is presented about a 19-year-old male with LGS who experienced breakthrough seizures, significant cognitive and behavioral challenges, and rare psychotic symptoms like hallucinations and self-harm.
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Background: Multiple sclerosis (MS) is a neurological disorder with demyelination of neuronal matter, especially of white matter, with multiple episodes occurring temporally. It has been associated with multiple neurological and psychiatric sequelae. Depression and other affective symptoms are commonly associated with MS.

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Key Clinical Message: The case highlights an unusual presentation where sleep issues preceded psychotic symptoms, implying link between disrupted sleep and psychosis onset. Earlier symptoms were viewed as depression but may have signaled psychosis exacerbated by insomnia.

Abstract: Sleep disorders, prevalent yet frequently overlooked in individuals with psychotic disorders, have significant associations with the onset and severity of psychosis.

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Background: Primary Sjögren's syndrome (pSS) is recognized for its autoimmune origin. Its hallmark symptoms, dry eyes and mouth, result from glandular inflammation. Prior literature indicates that pSS not only affects the peripheral system but also involves the central nervous system (CNS), giving rise to various neuropsychiatric symptoms.

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Article Synopsis
  • The study assessed mental health and cognition in patients with chronic diseases visiting the Emergency Department, using tools like the WHO well-being Index, Six-item screener, and CLOX-1 test.
  • Chronic diseases were especially common in individuals aged 51-70, with diabetes being the most prevalent, and significant symptoms like fever and gastrointestinal bleeding were noted.
  • Results showed that lower mental well-being scores were linked to poorer cognitive assessments, highlighting the importance of evaluating mental health even in patients with cognitive impairments in the ED.
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Objective: Our study aims to examine the risk factors for comorbid psychosis in pediatric patients hospitalized for anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis and its impact on hospital outcomes.

Methods: We conducted a cross-sectional study using the nationwide inpatient sample (NIS 2018-2019). We included 3,405 pediatric inpatients (age 6-17 years) with a primary discharge diagnosis of anti-NMDAR encephalitis.

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Myocardial infarction (MI) can have significant physical and mental consequences. Depression is a prevalent psychiatric condition after MI which can reduce the quality of life and increase the mortality rates of patients. However, the connection between MI and depression has remained under-appreciated.

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Nearly 90% of Americans are exposed to a traumatic event at some point in their lives, and over 8% of those individuals will develop posttraumatic stress disorder (PTSD). Our study examined the demographic differences and psychiatric comorbidities in inpatients with PTSD with and without somatic symptom disorders (SSDs), using data from the Nationwide Inpatient Sample for 2018 and 2019. Our sample included 12,760 adult patients with a primary diagnosis of PTSD, which was further subdivided based on a codiagnosis of SSD.

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To review the best pharmacologic and nonpharmacologic interventions in the management of chronic pain in elderly patients with depression. A systematic review of the literature was performed following the PRISMA guidelines and using PubMed. Articles published from 2010 to 2020 were included in the search.

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