Astracondensatol D: A 6/6/5/6 Cycloartane Triterpenoid from .

Astracondensatol D (), a pentacyclic triterpenoid featuring an uncommon 6/6/5/6-fused ring system, along with its precursor astracondensatol E (), and two simplified 20(27)-octanorcycloastragenol derivatives ( and ) were isolated from for the first time. Classical NMR spectroscopic data, integrated with NMR and DP4+ calculations, unambiguously determined their absolute stereostructures. X-ray crystallography provided independent confirmation of the structure of compound .

Palatal Perforation Due to Nasal Myiasis in a Patient With Atrophic Rhinitis: A Case Report.

Atrophic rhinitis (AR) is a chronic nasal disease characterized by atrophy of the nasal mucosa and turbinates. Occasionally, nasal myiasis complicates AR. This case illustrates an uncommon complication of nasal myiasis, palatal perforation.

Novel Controlled Metabolic Accelerator for Obesity-Related HFpEF: The HuMAIN-HFpEF Randomized Clinical Trial.

Importance: Excess body fat plays a pivotal role in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). HU6 is a novel, controlled metabolic accelerator that enhances mitochondrial uncoupling resulting in increased metabolism and fat-specific weight loss.

Objective: To assess efficacy and safety of HU6 in reducing body weight, improving peak volume of oxygen consumption (VO2) and body composition among patients with obesity-related HFpEF.

A novel dominant-negative variant of IRF8 in a mother and son: Clinical, phenotypic and biological characteristics.

Background: The few reported patients with pathogenic IRF8 variants have manifested 2 distinct phenotypes: (1) an autosomal recessive severe immunodeficiency with significant neutrophilia and absence of or significant decrease in monocytes and dendritic cells and (2) a dominant-negative form with only a decrease in conventional type 2 dendritic cells (cDC2s) and susceptibility to mycobacterial disease.

Objectives: Genetic testing of a child with persistent EBV viremia identified a novel IRF8 variant: c.1279dupT (p.

Comprehensive in-silico characterization and expression pattern of calmodulin genes under various abiotic and biotic stresses in Indian mustard ().

Unlabelled: Calcium (Ca⁺) as a secondary messenger has a multidimensional role, including the growth and development of plants and the adaptive response to stress conditions. Calmodulin (CaM), a calcium-binding protein, uniquely binds with these Ca⁺ ions and transmits Ca⁺ signals. Calmodulin proteins have been well-reported in various plants for playing a role in abiotic and biotic stress signaling; however, a comprehensive analysis of the genes of Indian mustard () has not been studied much.

Engagement, user satisfaction, and the amplification of divisive content on social media.

Social media ranking algorithms typically optimize for users' revealed preferences, i.e. user engagement such as clicks, shares, and likes.

MXenes as Versatile Materials for Hydrogen Technology and Multifunctional Applications.

MXenes are the carbides and nitrides of transition metals which are two dimensional in structure. High surface area, remarkable hydrophilicity, enhanced electrical conductivity, and unique surface functional groups are some of the distinguished properties of MXenes. These features make them suitable for numerous applications across domains such as sensing, biomedicine, catalysis, and electromagnetic interference shielding followed by hydrogen generation and storage at the forefront.

A Rare, Atypical Case of Porcupine Quill Shot in the Glenoid Fossa: Case Report and Review of Literature.

Human injury due to porcupine quill attack is quite unusual, as their interaction is very rare owing to their habitat. However encroachment into their wildlife can cause grave injuries due to their quills, which are modified keratin having backward facing sharp barbs. The injuries resulting from porcupine quill may cause pain, infection, foreign body reactions, vascular trauma, gastric perforations and are difficult to retrieve because of their structure.

To Study the Incidence of Biofilm Formation, its Microbiology and its Effect on the Development of Acute and Chronic Rhinosinusitis- A Prospective Study.

Bacterial biofilms are organised complex structures having polymicrobial nature in a single community, which provide protection to bacteria from antibiotics by various means. The aim of our study was to determine the prevalence of biofilm-forming bacteria in clinical isolates of acute and chronic rhinosinusitis (ARS and CRS) patients with sinonasal mucopurulence. To know the incidence of bacterial biofilms in patient with ARS and CRS, to study the microbiology of bacterial biofilms in ARS and CRS, to assess the role and effects of biofilm in ARS and CRS and to correlate the association between the formation of the biofilm and development of rhinosinusitis.

Vision Loss in Neurocysticercosis: A Systematic Review of Case Reports and Series.

Background And Purpose: Neurocysticercosis is a parasitic infection caused by larvae that leads to various neurological symptoms, including vision loss. This systematic review analyzed cases of vision loss associated with neurocysticercosis to assess its etiology and vision outcomes.

Methods: Following PRISMA guidelines, the review included reports on human subjects with vision loss due to neurocysticercosis and is registered with PROSPERO (CRD42024556278).

An interesting case of subacute sclerosing panencephalitis presenting with Balint's syndrome and dysautonomia.

Subacute sclerosing panencephalitis (SSPE) is a rare, progressive neurodegenerative disorder caused by persistent aberrant measles virus infection. It is characterized by behavioral changes, cognitive decline with deterioration in academic performance, visual dysfunction, focal or generalized seizures ,myoclonus, spasticity, mutism and akinesia ultimately leading to a vegetative state. Balint's syndrome, characterized by the triad of simultagnosia, optic ataxia, and oculomotor apraxia, as an initial presenting feature of SSPE is rare.

Fertility in non-classic lipoid CAH - A case report and review of the literature.

Introduction: Non-classic lipoid congenital adrenal hyperplasia (LCAH) presents with adrenal insufficiency but typically lacks a gonadal phenotype or features a delayed-onset gonadal presentation. Information on fertility outcomes in affected individuals is limited.

Case Presentation: We describe an adult male with severe, early-onset primary adrenal insufficiency, yet normal fertility, diagnosed in mid-adulthood with compound heterozygous STAR gene variants, including both known and novel mutations.

LC-MS analysis and antioxidant, antibacterial, and antidiabetic activity of Jumli Marshi rice from Nepal: An in vitro and in silico investigation to validate their potential as a functional food.

Jumli Marshi (J. Marshi), a native rice cultivar in Nepal, is gaining popularity owing to its health benefits for obesity, hypertension, and diabetes. However, scientific evidence verifying its therapeutic potential is lacking until November 2024.

SARS-CoV-2 Alchemy: Understanding the dynamics of age, vaccination, and geography in the evolution of SARS-CoV-2 in India.

Background: COVID-19 pandemic had unprecedented global impact on health and society, highlighting the need for a detailed understanding of SARS-CoV-2 evolution in response to host and environmental factors. This study investigates the evolution of SARS-CoV-2 via mutation dynamics, focusing on distinct age cohorts, geographical location, and vaccination status within the Indian population, one of the nations most affected by COVID-19.

Methodology: Comprehensive dataset, across diverse time points during the Alpha, Delta, and Omicron variant waves, captured essential phases of the pandemic's footprint in India.

Fe-2,5-furandicarboxylate Metal Organic Frameworks with Rare Building Blocks and a Ligand that can be Biomass-Derived as Effective Catalysts for Selective Nitroarene Reduction.

We report two three-dimensional metal-organic frameworks constructed from Fe3+ and the ligand, 2,5-furandicarboxylate (FDC) that can be derived from biomass. One contains an unprecedented infinite-rod-shaped building unit, and the other is the first crystalline framework of FDC that contains solely iron in the metal nodes. The materials are formed as microcrystals and their structures determined using 3D-electron diffraction with the bulk confirmed by powder XRD.

Insights Into the Conformational Dynamics of the Cytoplasmic Domain of Metal-Sensing Sensor Histidine Kinase ZraS.

ZraS is a metal sensor integral to ZraPSR, a two-component signaling system found in enterobacters. It belongs to a family of bifunctional sensor histidine kinases (SHKs) and is speculated to sense zinc-induced stress on the bacterial envelope. Information on the structure-function relationship of sensor kinases is elusive due to the lack of full-length structures, intrinsically dynamic behavior, and difficulty trapping them in active state conformations.

The infiltration of microplastics in human systems: Gastrointestinal accumulation and pathogenic impacts.

Microplastic particles have become ubiquitous in various ecosystems due to a drastic increase in plastic use and its consequent litter. The biological effects of these plastic particles on aquatic fauna are well-documented. However, the study of their accumulation and subsequent impact on terrestrial flora and fauna is in its initial stages.

Early White Matter Microstructure Alterations in Infants with Down Syndrome.

Importance: Down syndrome, resulting from trisomy 21, is the most prevalent chromosomal disorder and a leading cause of intellectual disability. Despite its significant impact on brain development, research on the white matter microstructure in infants with Down syndrome remains limited.

Objective: To investigate early white matter microstructure in infants with Down syndrome using diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI).

Role of nanobionics to improve the photosynthetic productivity in plants and algae: an emerging approach.

The domain of nanobionics has gained attention since its inception due to its potential applicability in plant, microalgal treatments, productivity enhancement. This review compares the intake and mobilization of nanoparticles (NPs) in plant and algal cell. In plants, NPs enter from root or other openings, and then carried by apoplastic or symplastic transport and accumulated in various parts, whereas in algae, NPs enter via endocytosis, passive transmission pathways, traverse the algal cell cytoplasm.

Phyllodes Tumor, A Cytomorphologic Study of 17 Cases with Histologic Correlation.

Background & Objective: Phyllodes tumor (PT) is a rare fibroepithelial tumor of the breast exhibiting varied clinicopathologic behavior, ranging from benign to borderline to frankly malignant, based on the presence of infiltrative margins, stromal overgrowth, stromal atypia, cellularity, and mitotic activity. In this study, a detailed cytomorphological study of cases of PT with the clinical and histological correlation was performed.

Methods: A cytomorphological study of 17 cases of histologically proven PT diagnosed between Jan 2014 and July 2021 was done retrospectively.

Nano Drug Delivery Carriers (Nanocarriers): A Promising Targeted Strategy in Tuberculosis and Pain Treatment.

Background: Tuberculosis (TB) and chronic pain are global health concerns that affect millions of people, often requiring long-term, effective treatment strategies. The conventional therapies used to manage these conditions come with significant limitations. In TB, long treatment durations, poor compliance, drug resistance, and toxicity of first-line drugs are key challenges.