Publications by authors named "Sashko Georgiev Spassov"
New Findings: What is the central question of the study? Does respiratory support ensure blood gas homeostasis and the relevance of experimental outcomes? What is the main finding and its importance? Spontaneous breathing during surgical intervention under anaesthesia results in impaired gas exchange and loss of diaphragm muscle strength in rats. Subsequent short-term mechanical ventilation restored blood gas homeostasis and diaphragm muscle strength. Blood gas homeostasis interferes substantially with experimental conditions and may alter study results.
View Article and Find Full Text PDFArticle Synopsis
- The document addresses an error in the original article identified by the DOI: 10.1155/2017/3715037.!
- It provides corrective information necessary to clarify the content or findings of the original study.!
- The corrections aim to enhance the accuracy and reliability of the research presented in the article.!
Article Synopsis
- * In a study with mice, using moderate tidal volumes during ventilation led to high levels of reactive oxygen species (ROS), which were prevented with supplemental HS inhalation at 80 parts per million.
- * HS appears to activate the signaling protein Akt, which plays a critical role in mitigating VILI by reducing both inflammation and oxidative stress, while blocking Akt worsens lung injury despite HS use.