The Keratoconus Outcome Research Questionnaire: A Cross-Cultural Validation Study of the Danish Version.

Purpose: To evaluate the psychometric properties of the Danish Keratoconus Outcome Research Questionnaire (KORQ).

Methods: Phase 1: Rasch analysis assessed the original Danish KORQ. Phase 2: Reengineering of the Danish KORQ to optimize the psychometric properties and functioning of the KORQ.

Gonadotropins in Keratoconus: The Unexpected Suspects.

Keratoconus (KC) is the most common ectatic corneal disease with a significant visual acuity burden. The actual burden is intangible given that KC can disrupt daily activities (reading, driving, and various career paths). Despite decades of research and clinical studies, the etiology, onset, and pathobiology of KC remain a mystery.

Incidence and prevalence of keratoconus in Denmark - an update.

Purpose: To describe the annual incidence rate of keratoconus in Denmark 1995-2015 and prevalence of keratoconus in the National Danish Patient Register 1977-2015.

Methods: All patients diagnosed with keratoconus in the National Danish Patient Register 1977-2015 were included in the study. The annual incidence rates and the overall prevalence of diagnosed keratoconus in the register were calculated using life tables from the general Danish population.

A nationwide population-based study of social demographic factors, associated diseases and mortality of keratoconus patients in Denmark from 1977 to 2015.

Purpose: To study sociodemographic factors, associated diseases and survival of Danish keratoconus patients.

Methods: All patients diagnosed with keratoconus 1977-2015 (n = 2679) were matched to 10 persons who had not been diagnosed with keratoconus (n = 26 790). Conditional logistic regression assessed whether sociodemographic factors and specific systemic diseases were associated with the odds of keratoconus.

Prolactin-Induced Protein is a novel biomarker for Keratoconus.

Purpose: The purpose of the study was to investigate the role of Prolactin-Induced Protein (PIP) as a predictive biomarker for Keratoconus (KC).

Participants: This study included one hundred and forty-seven patients with KC (105 male, 42 female), and sixty healthy controls (27 male, 33 female).

Methods: Tears, plasma and saliva samples were collected from all participants.

Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein.

Keratoconus (KC) is the most common ectatic corneal disease, with clinical findings that include discomfort, visual disturbance and possible blindness if left untreated. KC affects approximately 1:400 to 1:2000 people worldwide, including both males and females. The aetiology and onset of KC remains a puzzle and as a result, the ability to treat or reverse the disease is hampered.

Repeatability, reproducibility, and age dependency of dynamic Scheimpflug-based pneumotonometer and its correlation with a dynamic bidirectional pneumotonometry device.

Purpose: To assess the repeatability, reproducibility, and age dependency of dynamic Scheimpflug-based pneumotonometry (Corvis)-generated parameters and their correlation with dynamic bidirectional pneumotonometry device [Ocular Response Analyzer (ORA)] measurements [corneal hysteresis (CH) and corneal resistance factor (CRF)].

Methods: Eyes of 29 healthy participants between 20 and 30 years old were measured using Corvis and ORA. Measurements were performed twice in a row and repeated after 1 week.

Dynamic Scheimpflug-based assessment of keratoconus and the effects of corneal cross-linking.

Purpose: To evaluate the ability of the Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany) to distinguish between normal and keratoconic corneas and detect the possible stiffening effect of corneal cross-linking (CXL) in vivo.

Method: A retrospective study including 86 eyes of 86 participants (27 patients with untreated keratoconus, 27 patients with CXL-treated keratoconus, and 32 normal patients). The prospective study included 9 keratoconic eyes measured 24 days before and 97 days after CXL.

Corneal biomechanical properties after LASIK, ReLEx flex, and ReLEx smile by Scheimpflug-based dynamic tonometry.

Purpose: To evaluate corneal biomechanical properties after LASIK, ReLEx flex, and the flap-free procedure ReLEx smile by Scheimpflug-based dynamic tonometry (Corvis ST) and non-contact differential tonometry (Ocular Response Analyzer, ORA).

Methods: Patients treated for high myopia (-10.5 to -5.

Graft rejection and graft failure after penetrating keratoplasty or posterior lamellar keratoplasty for fuchs endothelial dystrophy.

Purpose: To compare the frequency of rejection episodes and graft failure because of surgical complications or rejection after Descemet stripping automated endothelial keratoplasty (DSAEK) and penetrating keratoplasty (PK) for Fuchs endothelial dystrophy.

Methods: A total of 201 eyes of 201 consecutive patients with Fuchs endothelial dystrophy undergoing keratoplasty were included. One hundred two patients underwent DSAEK and 99 PK in the period January 1, 2000, to December 31, 2010.