Publications by authors named "Sashi Challa"
J Bone Miner Res
January 2015
Article Synopsis
- Identifying high-risk fracture patients is critical, with a study linking genetic factors (63 SNPs) to bone mineral density (BMD) and fracture risk, leading to the creation of two genetic risk scores (GRS63 and GRS16).
- While GRS63 showed some association with BMD, it did not correlate with changes in BMD; both GRSs were linked to fracture risk but had reduced effectiveness after adjusting for BMD.
- The addition of these genetic risk scores provided only minor improvements in predictive models, indicating their limited clinical utility for predicting fractures in elderly individuals when BMD is already considered.
