Publications by authors named "Sasha L Lynch"
Article Synopsis
- Coenzyme A (CoA) is essential for many enzymatic reactions in cells, and Mycobacterium tuberculosis (Mtb) uses its own CoA biosynthesis pathway as a potential target for new tuberculosis drugs.
- A study identified a small molecule inhibitor that specifically targets the CoA biosynthesis enzyme CoaBC in Mtb, showcasing its ability to effectively inhibit this enzyme.
- Metabolomic profiling after treatment with the inhibitor revealed changes in Mtb's pantothenate and CoA biosynthesis, confirming CoaBC as a viable drug target.
Article Synopsis
- Coenzyme A (CoA) is essential for life and plays a key role in metabolic processes, making its biosynthesis an attractive drug target, especially for treating Mycobacterium tuberculosis.
- The enzyme CoaBC, a bifunctional protein, is crucial for CoA production and its depletion is lethal to M. tuberculosis.
- Researchers have characterized the structure of CoaBC from Mycobacterium smegmatis and discovered new inhibitors that target a unique site on the CoaB enzyme, potentially leading to effective treatments for tuberculosis.
