Publications by authors named "Sasha Dyck Holzinger"

Aim: To explore clinical factors associated with perinatal arterial ischemic stroke (AIS) and periventricular venous infarction (PVI) in infants who develop unilateral cerebral palsy (CP).

Method: This was a case-control study. Data current to 2019 was extracted from the Canadian Cerebral Palsy Registry (CCPR).

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Background: A crowd-sourced Canadian platform that collects information across neurodevelopmental disabilities (NDDs) can (1) facilitate knowledge mobilization; (2) provide epidemiological data that can benefit knowledge, treatment, and advocacy; and (3) inform policy and resource allocation decisions. We obtained input from parents of children with NDDs about relevance and feasibility of questionnaire items as a first step to inform questionnaire development of a stakeholder-driven, national platform for data collection on children with NDDs.

Methods: A parent of a teenager with NDDs was a research partner on the project.

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Aim: To determine whether inequities in health outcomes for Indigenous Canadians are also present in cerebral palsy (CP) by comparing CP profiles between Indigenous and non-Indigenous children.

Method: Using the Canadian Cerebral Palsy Registry, we conducted a cross-sectional study. CP motor subtype, gross motor severity, comorbidities, perinatal adversity, preterm birth, and parental education were compared between 94 Indigenous (53 males, 41 females) and 1555 non-Indigenous (891 males, 664 females) children (all >5y).

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Article Synopsis
  • The study investigates characteristics present at 2 years old that distinguish children later diagnosed with cerebral palsy (CP) from those who receive a non-CP diagnosis by age 5.
  • It analyzes data from 1,683 children, examining factors like MRI results, birth status, and motor function classifications, comparing those eventually confirmed with CP to those diagnosed otherwise.
  • Findings suggest that normal MRI results, specific CP motor types (ataxic-hypotonic or dyskinetic), a lack of perinatal complications, and being born at term are linked to a higher chance of being diagnosed with non-CP by age 5, aiding in future diagnostic approaches.
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Objective: This study looks at what profile can be expected in children with cerebral palsy spectrum disorder (CP) and a normal MRI.

Methods: The data were excerpted from the Canadian Cerebral Palsy Registry database. Only patients who had undergone MRI were included in the analysis.

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