Publications by authors named "Sascha Bezemer"
Article Synopsis
- The study focuses on how the age of Plasmodium falciparum sporozoites (SPZ) in mosquitoes affects their infectivity and the immune response they trigger in humans, specifically examining SPZ that are 14, 17, and 20 days old.* -
- Results indicated that while the number and viability of SPZ did not change with age, their motility decreased significantly over time, and the infectivity of SPZ dropped notably from 14 to 20 days.* -
- Additionally, immune responses showed that macrophages were more effective at taking up SPZ at 14 days, resulting in higher expression of inflammatory markers compared to those that were 20 days old.*
Glutaminyl cyclase (QC) modifies N-terminal glutamine or glutamic acid residues of target proteins into cyclic pyroglutamic acid (pGlu). Here, we report the biochemical and functional analysis of QC. We show that sporozoites of QC-null mutants of rodent and human malaria parasites are recognized by the mosquito immune system and melanized when they reach the hemocoel.
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