Publications by authors named "Sasanka Handunnetti"
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Synopsis of recent research by authors named "Sasanka Handunnetti"
- Sasanka Handunnetti's recent research focuses on the effectiveness and long-term outcomes of various targeted therapies for hematological malignancies, particularly chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), with notable emphasis on venetoclax and ibrutinib combinations.
- Key findings highlight the potential for durable responses and treatment-free remissions in certain patient populations, as evidenced by long-term results from a phase 2 trial examining venetoclax-ibrutinib therapy, which reported sustained complete remission rates over seven years.
- Additionally, the research underscores the importance of understanding resistance mechanisms to targeted therapies, including the emergence of specific mutations in CLL and the prognostic implications of TP53 mutations in MCL, advocating for the integration of mutation testing in clinical practice to identify high-risk patients.
