Improving Renal Tumor Biopsy Prognostication With BAP1 Analyses.

Context.—: Active surveillance of small renal masses highlights the need for accurate prognostication of biopsies.

Objective.

Primary Renal Sarcoma With Gene Fusion in an 18-Year-Old Male: A Rare Lesion With a Diagnostic Quandary.

Primary renal sarcoma with gene fusion is a rare tumor with only 7 cases reported in the English literature. The morphologic features of this tumor strikingly overlap with clear cell sarcoma of the kidney and synovial sarcoma. Accurate diagnosis can be challenging.

Multimodal depiction of a rare immature gastric teratoma from fetus to infant.

Immature gastric teratomas are rare gastrointestinal tumors. Presented here are imaging findings of this neoplasm which was first seen via antenatal ultrasound. Subsequent fetal magnetic resonance imaging demonstrated a partially calcified mass that contained areas of diffusion restriction.

The Clinical Significance of Crohn Disease Activity at Resection Margins.

Context.—: Conflicting data about the clinical significance of microscopic Crohn disease (CD) activity at resection margins have led to varying practice patterns for routine reporting by pathologists.

Objective.

Short-term metformin treatment for clomiphene citrate-resistant women with polycystic ovary syndrome.

Objective: To evaluate the effect of a short-course pretreatment with metformin on hyperandrogenism, insulin resistance, cervical scores, and pregnancy rates in women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS).

Methods: Thirty-seven women with CC-resistant PCOS were randomly assigned to be pretreated with 500 mg of metformin or placebo 3 times per day for 2 cycles, and 100 mg of CC was given on days 5 through 9 of the second cycle in both groups. Luteinizing hormone (LH), follicle stimulating hormone (FSH), dehydroepiandrostendione sulfate (DHEAS), total testosterone (T), glucose, and insulin levels were measured at baseline and after the first cycle, as well as body mass index (BMI), cervical score, and pregnancy rate.